Interpret Your GI-MAP

What is Campylobacter?
Campylobacter is a type of bacteria that can infect the intestinal tract and cause foodborne illness. The two species most commonly linked to human infection are Campylobacter jejuni and Campylobacter coli. These bacteria thrive in the intestines of animals, especially poultry, and can survive in undercooked meat or contaminated water.

Why is Campylobacter Important?
Campylobacter is one of the most common causes of bacterial gastroenteritis worldwide. Infection can lead to:

• Diarrhea (sometimes bloody)
• Abdominal cramps and pain
• Nausea and vomiting
• Fever and fatigue
  

In more severe or prolonged cases, Campylobacter infection may contribute to:

• Post-infectious irritable bowel syndrome (IBS)
• Small intestinal bacterial overgrowth (SIBO)
• Reactive arthritis
• Autoimmune complications such as Guillain-Barré syndrome (a rare nerve condition)
  

How Did I Get Campylobacter?
Campylobacter is usually transmitted through:

• Eating undercooked poultry or meat
• Drinking unpasteurized milk or untreated water
• Cross-contamination in the kitchen (using the same cutting board or utensils for raw and cooked foods)
  Direct contact with infected animals (especially chickens or pets)
  

Even a small amount of bacteria can cause illness, and symptoms often begin 2–5 days after exposure.

What Does My Test Show?
Your test detected Campylobacter DNA in your stool sample, meaning that this bacteria is present in your digestive tract. This result suggests either an active or recent infection. If symptoms are ongoing, it may be contributing to intestinal inflammation, diarrhea, or abdominal pain.

Why Might Campylobacter Cause Symptoms?
Campylobacter releases toxins that irritate the intestinal lining, leading to inflammation and fluid loss. This can disrupt digestion, increase intestinal permeability (“leaky gut”), and alter the gut microbiome balance. In some people, it can trigger an exaggerated immune response that persists long after the infection clears, contributing to post-infectious IBS or ongoing food sensitivities.

Important Notes: Campylobacter infections can resolve on their own, but medical attention is needed for severe dehydration, high fever, or persistent symptoms. Reinfection can occur if food safety or hygiene practices are not carefully followed. In individuals with weakened immune systems, infection may become more serious or prolonged.

Conventional Management Options

1. Supportive care with hydration and electrolyte replacement
2. In some cases, antibiotics such as azithromycin or ciprofloxacin may be prescribed
3. Avoiding anti-diarrheal medications unless directed by a physician, as they may prolong infection
   
   

Functional Medicine Categories Approach

Microbial Balance Support

• Oregano oil
  
• Berberine
  
• Garlic extract (allicin)
  
• Black walnut 

Gut Barrier & Mucosal Support

• L-glutamine
  
• Aloe vera
  
• Marshmallow root
  
• Slippery elm
  

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
  
• Vitamin D
  
• Vitamin C
  
• Zinc carnosine 

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
  
• Prebiotic fibers (as tolerated)
  

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Clostridium difficile (C. difficile), Toxin A?
C. difficile is a type of bacteria that can live in the intestines. Some strains produce toxins that can cause inflammation and damage to the gut lining. Toxin A is one of the main toxins produced by this bacteria and is responsible for much of the diarrhea and intestinal irritation associated with C. difficile infections. It disrupts the tight junctions that hold intestinal cells together, leading to fluid loss, inflammation, and tissue injury.

Why is C. difficile Important?
C. difficile infections can range from mild diarrhea to severe inflammation of the colon (colitis). They are often associated with antibiotic use, which disrupts normal gut bacteria and allows C. difficile to overgrow. Symptoms may include:

• Watery diarrhea
• Abdominal pain and cramping 
• Fever
• Nausea
• Loss of appetite

In more severe cases, infection may lead to:

• Dehydration
• Bloody stools
• Toxic megacolon (rare but life-threatening)
• Recurrence after treatment

How Did I Get C. difficile?
C. difficile is spread through spores that can survive on surfaces for long periods. These spores are resistant to heat and many cleaning agents. You can get infected by: Recent or frequent antibiotic use, Hospital or healthcare exposure, Contact with contaminated surfaces (bathrooms, medical equipment) or Poor hand hygiene after contact with infected individuals or surfaces.

What Does My Test Show?
Your test detected DNA for C. difficile Toxin A, which means that the bacteria are capable of producing this toxin. This result indicates possible active infection or colonization. If symptoms like diarrhea, cramping, or bloating are present, it’s likely that Toxin A is contributing to gut irritation and inflammation.

Why Might C. difficile Cause Symptoms?
The toxins produced by C. difficile damage the gut lining and trigger an inflammatory immune response. This disrupts the normal gut barrier, leading to diarrhea, mucus production, and sometimes bleeding. The infection also reduces healthy gut bacteria, making it harder for your microbiome to recover and resist future infections.

Important Notes: C. difficile infections can recur, even after successful treatment. Reinfection risk increases with continued antibiotic exposure or poor gut diversity. Medical supervision is essential if symptoms persist or worsen.

Conventional Management Options

• Antibiotics specifically targeting C. difficile, such as vancomycin, fidaxomicin, or metronidazole
• Discontinuing the antibiotic that caused the imbalance, if possible
• In severe or recurrent cases, fecal microbiota transplantation (FMT) may be considered
• Supportive care with fluids and electrolytes

Functional Medicine Categories Approach

Microbial Balance Support

• Berberine
• Oregano oil
• Garlic extract (allicin)
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus, Bifidobacterium, and spore-forming species)
• Prebiotic fibers (as tolerated)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Clostridium difficile (C. difficile), Toxin B?
C. difficile is a type of bacteria that can live in the intestines. Some strains produce toxins that cause inflammation and tissue damage in the colon. Toxin B is one of the two main toxins made by this bacteria and is considered the more potent of the two. It disrupts intestinal cells, increases permeability of the gut lining, and causes significant inflammation and diarrhea.

Why is C. difficile Important?
C. difficile infections are a leading cause of antibiotic-associated diarrhea. They often develop when antibiotics disrupt healthy gut bacteria, allowing C. difficile to overgrow. Symptoms can include:

• Watery diarrhea
• Abdominal pain and cramping
• Nausea and loss of appetite
• Fever
• Fatigue

In more severe cases, infection may cause:

• Bloody diarrhea
• Severe dehydration
• Inflamed or ulcerated colon (pseudomembranous colitis)
• Recurrence after treatment

How Did I Get C. difficile?
C. difficile spreads through spores found in feces and on contaminated surfaces. These spores can survive for long periods and are resistant to many cleaning products. Infection can occur from:

• Recent or repeated antibiotic use
• Exposure in hospitals or healthcare facilities
• Contact with contaminated surfaces or objects
• Poor hand hygiene after contact with an infected person

What Does My Test Show?
Your test detected DNA for C. difficile Toxin B, indicating that the bacteria in your digestive tract are capable of producing this toxin. This finding suggests possible active infection or colonization. If you are experiencing digestive symptoms, the toxin may be contributing to inflammation, diarrhea, and gut imbalance.

Why Might C. difficile Cause Symptoms?
Toxin B disrupts the intestinal lining by damaging the cells that protect the colon, leading to inflammation, mucus production, and fluid loss. This can cause loose stools, pain, and nutrient malabsorption. When both Toxin A and Toxin B are present, symptoms may be more severe.

Important Notes: C. difficile infections can recur even after successful treatment, especially if the gut microbiome has not fully recovered. Reinfection can occur through environmental exposure or ongoing antibiotic use. Prompt medical attention is necessary for severe or persistent symptoms.

Conventional Management Options

• Antibiotics targeted specifically to C. difficile, such as vancomycin, fidaxomicin, or metronidazole
• Stopping the antibiotic that triggered the imbalance, if appropriate
• Fecal microbiota transplantation (FMT) for recurrent or severe cases
• Supportive care with hydration and electrolyte replacement

Functional Medicine Categories Approach

Microbial Balance Support

• Berberine
• Oregano oil
• Garlic extract (allicin)
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus, Bifidobacterium, and spore-forming species)
• Prebiotic fibers (as tolerated)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Enterohemorrhagic Escherichia coli (EHEC)?
Enterohemorrhagic E. coli, often abbreviated as EHEC, is a type of pathogenic E. coli bacteria that produces powerful toxins known as Shiga toxins. These toxins can damage the lining of the intestines and lead to serious gastrointestinal symptoms. The most well-known strain of EHEC is E. coli O157:H7, but other strains can cause similar illness.

Why is EHEC Important?
EHEC infections are significant because they can cause both mild and severe gastrointestinal illness. Common symptoms include:

• Watery or bloody diarrhea
• Abdominal cramping
• Nausea
• Fatigue
• Low-grade fever (sometimes absent)

In some individuals—especially children, the elderly, or those with weakened immune systems—EHEC can cause a serious complication called hemolytic uremic syndrome (HUS), which affects the kidneys and can be life-threatening if not treated promptly.

How Did I Get EHEC?
EHEC is typically acquired through contaminated food or water, such as:
Eating undercooked ground beef or unpasteurized dairy products

• Consuming raw vegetables or sprouts that were contaminated during growing or handling
• Drinking contaminated water
• Direct contact with infected animals (especially cattle) or contaminated surfaces

Person-to-person transmission can also occur, particularly in households or childcare settings, if proper hygiene isn’t followed.

What Does My Test Show?
Your test detected DNA for Enterohemorrhagic E. coli, which means that this toxin-producing strain was found in your stool sample. This result indicates a potential infection or recent exposure. If symptoms like diarrhea, cramping, or blood in the stool are present, it suggests that this bacteria may be actively contributing to gut inflammation and intestinal injury.

Why Might EHEC Cause Symptoms?
EHEC releases Shiga toxins that damage the cells lining the intestine. This can lead to bleeding, fluid loss, and inflammation, resulting in diarrhea and abdominal pain. The toxins can also enter the bloodstream and, in severe cases, affect other organs like the kidneys, leading to HUS.

Important Notes:

• Antibiotic use is generally not recommended for EHEC infections, as it can increase toxin release and worsen symptoms.
  
• Hydration is critical, as diarrhea can lead to fluid and electrolyte loss.
  
• Medical attention is needed if you experience bloody diarrhea, decreased urination, or signs of dehydration.
  

Conventional Management Options

• Supportive care with fluids and electrolytes
• Avoiding antibiotics and anti-diarrheal medications unless specifically advised by a physician
• Hospitalization and monitoring in severe cases or suspected HUS 

Functional Medicine Categories Approach

Microbial Balance Support

• Garlic extract (allicin)
• Berberine
• Oregano oil
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species; avoid in acute bloody diarrhea)
• Prebiotic fibers (introduced gradually after recovery)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Escherichia coli O157 (E. coli O157)?
E. coli O157 is one of the most common and serious strains of enterohemorrhagic E. coli (EHEC). It produces toxins known as Shiga toxins, which can cause significant damage to the intestinal lining and, in some cases, lead to complications outside the gut. While most E. coli are harmless and part of the normal gut flora, E. coli O157 is a pathogenic strain capable of causing severe foodborne illness.

Why is E. coli O157 Important?
This strain is particularly important because it is one of the leading causes of foodborne outbreaks worldwide. It can cause a wide range of digestive symptoms, including:

• Watery or bloody diarrhea
• Abdominal cramping and pain
• Nausea and vomiting
• Fatigue
• Low-grade or absent fever

In severe cases, E. coli O157 infection may lead to hemolytic uremic syndrome (HUS)—a serious condition that can cause anemia, low platelet counts, and kidney failure. This complication is more common in children, older adults, and those with weakened immune systems.

How Did I Get E. coli O157?
Infection usually occurs after ingesting contaminated food or water. Common sources include:

• Undercooked ground beef or contaminated meat
• Unpasteurized milk or juice
• Raw vegetables, lettuce, or sprouts grown in contaminated soil or water
• Contaminated drinking or recreational water
• Direct contact with animals or contaminated surfaces (petting zoos, farms)

Even a small number of bacteria can cause illness, and person-to-person spread can occur in households or childcare settings if hygiene practices are poor.

What Does My Test Show?
Your test detected DNA for E. coli O157, meaning this specific toxin-producing strain was found in your stool sample. This indicates a possible active or recent infection. If you are experiencing diarrhea (especially bloody), cramping, or fatigue, this strain is likely contributing to intestinal inflammation and irritation.

Why Might E. coli O157 Cause Symptoms?
The Shiga toxins produced by E. coli O157 attach to intestinal cells and damage their lining, leading to bleeding, inflammation, and fluid loss. These toxins can also circulate in the bloodstream, potentially damaging the kidneys and other organs. Because antibiotics can increase toxin release, they are generally avoided in managing this infection.

Important Notes:

• Do not use antibiotics or anti-diarrheal medications unless directed by a medical provider, as they can worsen toxin release.
  
• Stay hydrated to prevent dehydration and support recovery.
  
• Seek immediate medical care if you experience bloody diarrhea, reduced urination, or severe fatigue, which could indicate HUS development.
  

Conventional Management Options

• Supportive care with fluids and electrolytes
• Avoidance of antibiotics and anti-motility drugs unless specifically directed by a physician
• Hospitalization and monitoring for kidney function in severe or high-risk cases

Functional Medicine Categories Approach

Microbial Balance Support

• Garlic extract (allicin)
• Berberine
• Oregano oil
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species; avoid during active bloody diarrhea phase)
• Prebiotic fibers (added gradually once symptoms resolve)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Enteroinvasive Escherichia coli (EIEC)/Shigella?
Enteroinvasive E. coli (EIEC) is a type of E. coli that behaves very similarly to Shigella, the bacteria that causes shigellosis. Both can invade the lining of the large intestine, causing inflammation and tissue damage. Because they share similar genetic and pathogenic traits, laboratory testing often groups them together. These infections can lead to significant gastrointestinal distress and, in some cases, fever and systemic symptoms.

Why is EIEC/Shigella Important?
EIEC and Shigella infections cause inflammatory diarrhea and can lead to intestinal ulceration. Common symptoms include:

• Watery or bloody diarrhea
• Abdominal pain and cramping
• Fever and chills
• Fatigue
• Nausea and loss of appetite

In more severe cases, infection may cause:

• Dehydration
• Rectal pain or urgency
• Inflamed or ulcerated colon (colitis)
• Post-infectious irritable bowel syndrome (IBS)

How Did I Get EIEC/Shigella?
These bacteria are spread through the fecal-oral route, meaning infection occurs when small amounts of fecal matter are ingested. This can happen through:

• Eating contaminated food or drinking contaminated water
• Poor hand hygiene (especially after bathroom use or diaper changes)
• Person-to-person contact in childcare, healthcare, or household settings
• Exposure to contaminated surfaces or food handled by infected individuals

EIEC and Shigella are especially common in areas with limited access to clean water or sanitation.

What Does My Test Show?
Your test detected DNA for Enteroinvasive E. coli/Shigella, meaning that this type of bacteria is present in your stool sample. This indicates either an active or recent infection. If symptoms like diarrhea, abdominal pain, or fever are present, it suggests inflammation of the colon caused by these bacteria.

Why Might EIEC/Shigella Cause Symptoms?
These bacteria invade and destroy the cells lining the intestinal wall, leading to inflammation, mucus production, and bleeding. This process disrupts digestion and fluid balance, resulting in diarrhea and cramping. The immune response to this infection can also cause fatigue and fever.

Important Notes:

• Hydration is essential during recovery. Severe dehydration may require medical attention.
  
• Antibiotics may be used in some cases, but treatment depends on symptom severity and resistance patterns.
  
• Good hand hygiene is critical to prevent reinfection or spreading the bacteria to others.
  

Conventional Management Options

• Supportive care with fluids and electrolytes
• Antibiotics such as azithromycin or ciprofloxacin, only if recommended by a healthcare provider
• Avoiding anti-diarrheal medications unless specifically directed, as they can prolong infection
• Rest and proper nutrition during recovery

Functional Medicine Categories Approach

Microbial Balance Support

• Garlic extract (allicin)
• Berberine
• Oregano oil
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species; use after acute infection resolves)
• Prebiotic fibers (introduced gradually post-recovery)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Enterotoxigenic Escherichia coli (ETEC)?
Enterotoxigenic E. coli (ETEC) is a strain of E. coli that produces two types of toxins — heat-labile (LT) and heat-stable (ST) — which stimulate the intestines to secrete excess fluid and electrolytes. This leads to watery diarrhea and other digestive symptoms. ETEC is one of the most common causes of traveler’s diarrhea and is a frequent cause of foodborne illness in developing countries.

Why is ETEC Important?
ETEC is known for causing self-limited but uncomfortable diarrheal illness. Symptoms can range from mild to severe and typically include:

• Watery diarrhea
• Abdominal cramps
• Bloating and gas
• Nausea
• Low-grade fever
• Fatigue and weakness

While most cases resolve on their own, prolonged diarrhea can lead to dehydration, nutrient loss, and fatigue. In some individuals, especially children or those with weakened immune systems, infection can be more severe and may contribute to post-infectious IBS or gut microbiome disruption.

How Did I Get ETEC?
ETEC spreads through ingestion of contaminated food or water. Common sources include:

• Eating raw or undercooked vegetables washed with contaminated water
• Drinking untreated or unfiltered water
• Consuming food handled by someone who is infected
• Traveling to areas with poor sanitation or unsafe drinking water

Infections are common in areas without adequate water treatment, and travelers often contract ETEC when visiting these regions.

What Does My Test Show?
Your test detected DNA for Enterotoxigenic E. coli (LT/ST), which means this toxin-producing strain was found in your stool sample. This indicates an active or recent infection that could be contributing to diarrhea, bloating, or cramping.

Why Might ETEC Cause Symptoms?
The toxins produced by ETEC interfere with normal intestinal function by stimulating fluid secretion into the gut. This leads to watery stools, dehydration, and abdominal discomfort. While the infection is typically short-lived, it can disrupt the balance of the gut microbiome and contribute to longer-term digestive symptoms in sensitive individuals.

Important Notes:

• ETEC infection usually resolves within a few days but may last longer without proper hydration and rest.
  
• Avoiding contaminated food and water sources is key to preventing reinfection.
  
• Medical attention is needed if diarrhea is severe, bloody, or accompanied by high fever or dehydration.
  

Conventional Management Options

• Hydration and electrolyte replacement are the mainstays of treatment
• In some cases, antibiotics like azithromycin or ciprofloxacin may be prescribed (especially for travelers)
• Anti-diarrheal medications may help with symptoms, but only under medical supervision
• Rest and gradual reintroduction of bland, easy-to-digest foods

Functional Medicine Categories Approach

Microbial Balance Support

• Garlic extract (allicin)
• Berberine
• Oregano oil
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after recovery)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Shiga-like Toxin Escherichia coli (stx1)?
Shiga-like toxin Escherichia coli (stx1) refers to strains of E. coli that produce a toxin similar to that of Shigella dysenteriae. This toxin, called Shiga toxin 1 (stx1), can damage the intestinal lining and interfere with normal gut function. While not all E. coli strains are harmful, those that carry the stx1 gene can cause moderate to severe intestinal illness. These strains are often grouped under the term Shiga toxin-producing E. coli (STEC) or enterohemorrhagic E. coli (EHEC).

Why is stx1 Important?
The stx1 toxin can lead to inflammation and bleeding in the intestines. Infection symptoms can vary from mild to severe and may include:

• Watery or bloody diarrhea
• Abdominal pain and cramping
• Nausea and vomiting
• Fatigue
• Low-grade or no fever

In severe cases, the toxin can enter the bloodstream and cause hemolytic uremic syndrome (HUS), which affects the kidneys and blood cells. This is more common in young children, older adults, and those with weakened immune systems.

How Did I Get stx1?
Shiga-like toxin–producing E. coli are typically spread through contaminated food, water, or contact with infected animals. Common sources include:

• Undercooked ground beef or other meats
• Unpasteurized milk, cheese, or juices
• Raw vegetables or sprouts contaminated during harvesting or washing
• Contact with infected animals or contaminated environments (e.g., farms, petting zoos)
• Person-to-person transmission via poor hygiene practices

What Does My Test Show?
Your test detected DNA for E. coli carrying the stx1 gene, which means a toxin-producing strain of E. coli was found in your stool sample. This suggests recent or active infection. If symptoms like diarrhea, abdominal pain, or fatigue are present, this bacteria may be contributing to inflammation and irritation in your intestines.

Why Might stx1 Cause Symptoms?
The stx1 toxin binds to intestinal cells, disrupting their function and damaging the mucosal lining. This leads to bleeding, inflammation, and fluid loss. In some cases, the toxin can travel to the bloodstream and impact other organs, particularly the kidneys. Because antibiotic treatment can sometimes increase toxin release, it is generally avoided unless specifically recommended by a physician.

Important Notes:

• Antibiotics are typically not recommended, as they can worsen toxin release.
  
• Hydration and rest are key to recovery. 
• Seek immediate medical care if you develop bloody diarrhea, signs of dehydration, or decreased urination.
  

Conventional Management Options

• Supportive care with fluids and electrolytes
• Avoidance of antibiotics and anti-motility medications unless directed by a healthcare provider
• Hospital monitoring for severe cases or suspected HUS
• Gradual return to normal diet after symptoms improve

Functional Medicine Categories Approach

Microbial Balance Support

• Garlic extract (allicin)
• Berberine
• Oregano oil
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species; avoid during active bloody diarrhea)
• Prebiotic fibers (added gradually once symptoms resolve) 

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Shiga-like Toxin Escherichia coli (stx2)?
Shiga-like toxin Escherichia coli (stx2) refers to strains of E. coli that produce Shiga toxin 2, one of the two major toxins associated with Shiga toxin–producing E. coli (STEC). This toxin is often considered more potent than stx1 and is more strongly linked to severe complications such as hemolytic uremic syndrome (HUS). Like other toxin-producing E. coli, stx2 strains can cause gastrointestinal illness ranging from mild diarrhea to serious intestinal and kidney involvement.

Why is stx2 Important?
Infection with stx2-producing E. coli can cause significant intestinal inflammation and, in severe cases, systemic illness. Common symptoms include:

• Watery or bloody diarrhea
• Abdominal cramps and pain
• Fatigue and weakness
• Nausea and vomiting
• Low-grade or no fever

The stx2 toxin has a stronger association with hemolytic uremic syndrome (HUS) — a condition that can damage red blood cells, lower platelet counts, and impair kidney function. This makes stx2 infections more clinically serious than those caused by stx1 alone.

How Did I Get stx2?
Shiga-like toxin–producing E. coli (STEC) spreads through contaminated food, water, or direct contact with infected animals or humans. Common exposure routes include:

• Eating undercooked ground beef or other contaminated meats
• Drinking unpasteurized milk, juice, or other dairy products
• Consuming raw vegetables or sprouts contaminated during processing
• Contact with farm animals or their environments
• Person-to-person transmission through poor hygiene or contaminated surfaces

What Does My Test Show?
Your test detected DNA for E. coli carrying the stx2 gene, indicating the presence of a strain that produces Shiga toxin 2. This means there may be an active or recent infection contributing to your symptoms. If you are experiencing diarrhea, abdominal pain, or fatigue, this bacteria may be causing inflammation or irritation in your digestive system.

Why Might stx2 Cause Symptoms?
The stx2 toxin binds to receptors on the cells lining your intestines, disrupting their function and causing bleeding and inflammation. It can also cross into the bloodstream, where it may damage small blood vessels and affect the kidneys. Because antibiotic therapy can trigger increased toxin release, it is generally avoided unless medically necessary.

Important Notes:

• stx2-producing strains are associated with a higher risk of severe illness than stx1.
• Antibiotics and anti-diarrheal medications should not be used unless prescribed by a physician.
• Seek immediate medical attention if you experience bloody diarrhea, signs of dehydration, or reduced urine output.
  

Conventional Management Options

• Supportive care with fluids and electrolytes
• Avoidance of antibiotics and anti-motility agents unless specifically advised by a healthcare provider
• Close monitoring for kidney function in severe cases or suspected HUS
• Hospital care for individuals showing systemic symptoms or dehydration

Functional Medicine Categories Approach

Microbial Balance Support

• Garlic extract (allicin)
• Berberine
• Oregano oil
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species; avoid during active bloody diarrhea)
• Prebiotic fibers (added gradually post-recovery)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Salmonella?
Salmonella is a type of bacteria that can infect the intestinal tract and sometimes the bloodstream. It’s one of the most common causes of foodborne illness worldwide. There are many types (or “serotypes”) of Salmonella, but the two most common that cause human disease are Salmonella enteritidis and Salmonella typhimurium. These bacteria can survive in the intestines of animals and contaminate food during processing or handling.

Why is Salmonella Important?
Salmonella infection (called salmonellosis) typically causes acute gastrointestinal symptoms but can sometimes lead to longer-term complications. Common symptoms include:

• Diarrhea (sometimes bloody)
• Abdominal pain and cramping
• Fever and chills
• Nausea and vomiting
• Headache and muscle aches

In some individuals, infection can lead to:

• Dehydration and electrolyte imbalance
• Sepsis (bacteria entering the bloodstream)
• Reactive arthritis (joint pain after infection)
• Post-infectious IBS or prolonged gut inflammation

How Did I Get Salmonella?
Salmonella is usually spread through contaminated food or water. Common sources include:

• Undercooked eggs, poultry, or meat
• Unpasteurized milk or dairy products
• Raw produce (especially leafy greens and sprouts) contaminated during washing or handling
• Contact with infected animals (especially reptiles, birds, and pets)
• Poor hand hygiene after handling raw meat or using the bathroom
• Person-to-person transmission can also occur if proper hygiene isn’t practiced after bathroom use or diaper changes.

What Does My Test Show?
Your test detected DNA for Salmonella, indicating the presence of this bacteria in your stool sample. This suggests an active or recent infection. If symptoms such as diarrhea, fever, or abdominal pain are present, Salmonella may be contributing to intestinal inflammation or infection.

Why Might Salmonella Cause Symptoms?
Once inside the body, Salmonella invades intestinal cells and triggers inflammation, leading to fluid loss and diarrhea. It can also produce toxins that irritate the intestinal lining. In some cases, the infection can spread beyond the gut into the bloodstream or other organs, especially in individuals with weakened immunity. Even after recovery, inflammation may persist and affect digestion or gut balance.

Important Notes:

• Salmonella infections typically resolve within a week, but dehydration is a common concern.
  
• Antibiotics are usually reserved for severe cases or those involving systemic infection.
  
• Reinfection can occur if food safety and hygiene practices aren’t followed.
  
  

Conventional Management Options

Supportive care with fluids and electrolytes to prevent dehydration

• Antibiotics (such as ciprofloxacin or azithromycin) for severe or systemic infections
• Rest and gradual reintroduction of bland, easy-to-digest foods
• Avoidance of anti-diarrheal medications unless prescribed

Functional Medicine Categories Approach

Microbial Balance Support

• Garlic extract (allicin)
• Berberine
• Oregano oil
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after recovery)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Vibrio cholerae?
Vibrio cholerae is a type of bacteria that causes cholera, an intestinal infection that leads to severe watery diarrhea and dehydration. It produces a toxin (cholera toxin) that disrupts normal fluid regulation in the intestines, causing the body to lose large amounts of water and electrolytes. While cholera is rare in developed countries, mild or asymptomatic infections can still occur in areas with contaminated water or poor sanitation.

Why is Vibrio cholerae Important?
Vibrio cholerae infection can range from mild diarrhea to life-threatening dehydration. Common symptoms include:

• Watery diarrhea (often described as “rice water” stools)
• Abdominal cramping
• Nausea and vomiting
• Muscle cramps and weakness
• Rapid heartbeat or dizziness (due to dehydration)

In severe cases, dehydration can occur rapidly and may lead to shock or organ failure if untreated. Even mild infections can disrupt digestion and microbiome balance, especially in individuals with compromised gut health.

How Did I Get Vibrio cholerae?
Vibrio cholerae is spread primarily through contaminated food or water. Common sources include:

• Drinking untreated or contaminated water
• Eating raw or undercooked seafood (especially shellfish)
• Consuming food washed or prepared with contaminated water
• Poor sanitation or hygiene in areas with inadequate sewage treatment

Infection is most common in regions where water treatment is limited, but it can also occur during travel or after consuming contaminated seafood.

What Does My Test Show?
Your test detected DNA for Vibrio cholerae, which means this bacteria—or its genetic material—was found in your stool sample. This indicates an active or recent infection. If you are experiencing diarrhea or dehydration, this organism may be contributing to those symptoms by altering the intestinal fluid balance.

Why Might Vibrio cholerae Cause Symptoms?
The cholera toxin produced by Vibrio cholerae stimulates the intestines to secrete large amounts of fluid and electrolytes. This leads to watery stools, dehydration, and fatigue. The rapid loss of fluids can disrupt digestion, lower blood pressure, and cause severe electrolyte imbalances if not managed promptly.

Important Notes:

• Rapid rehydration is critical — cholera can cause life-threatening dehydration within hours in severe cases.
• Medical attention is essential for anyone with profuse watery diarrhea or signs of dehydration (dry mouth, dizziness, low urine output).
• Most infections resolve with proper hydration, but gut repair and microbiome support are often beneficial afterward.
  

Conventional Management Options

• Immediate oral or intravenous rehydration therapy (with electrolyte replacement)
• Antibiotics such as azithromycin or doxycycline in severe cases or outbreaks
• Zinc supplementation to support recovery, especially in children
• Rest and continued hydration throughout recovery

Functional Medicine Categories Approach

Microbial Balance Support

• Garlic extract (allicin)
• Berberine
• Oregano oil
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after acute symptoms resolve) 

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Yersinia enterocolitica?
Yersinia enterocolitica is a type of bacteria that infects the intestinal tract and sometimes the lymph nodes in the abdomen. It is part of the same bacterial family as Yersinia pestis (which causes plague), but Y. enterocolitica specifically affects the digestive system. Infection with this organism is known as yersiniosis, and it can mimic other gastrointestinal illnesses such as appendicitis or Crohn’s disease.

Why is Yersinia enterocolitica Important?
Yersinia enterocolitica infection can cause both acute and chronic gastrointestinal symptoms. Common signs and symptoms include:

• Abdominal pain (often in the lower right side)
• Fever
• Watery or bloody diarrhea
• Nausea and vomiting
• Loss of appetite

In some cases, infection can lead to:

• Post-infectious IBS or ongoing digestive issues
• Reactive arthritis (joint pain developing weeks after infection)
• Autoimmune reactions, including thyroid or joint-related immune activation
• Persistent inflammation of lymph nodes in the abdomen (mesenteric adenitis), which can mimic appendicitis

How Did I Get Yersinia enterocolitica?
Infection usually occurs from eating contaminated food or water. Common exposure sources include:

• Undercooked pork or contaminated meat products
• Unpasteurized milk or dairy
• Contaminated water or ice
• Cross-contamination in kitchens (raw meat to ready-to-eat foods)
• Contact with infected animals (especially pigs) or contaminated environments

Yersinia can survive and multiply even at refrigerator temperatures, making it a risk in improperly stored foods.

What Does My Test Show?
Your test detected DNA for Yersinia enterocolitica, meaning this bacteria was found in your stool sample. This indicates either an active or recent infection. If symptoms such as diarrhea, fever, or right-sided abdominal pain are present, this organism may be contributing to inflammation in your intestines or lymph nodes.

Why Might Yersinia enterocolitica Cause Symptoms?
This bacteria attaches to and invades the lining of the small intestine, triggering inflammation and damaging intestinal tissue. It can also travel to nearby lymph nodes, causing pain that mimics appendicitis. The immune response to Yersinia can persist long after the infection clears, contributing to lingering gut symptoms or reactive joint pain.

Important Notes:

• Yersinia infection may appear similar to appendicitis, so accurate testing is key for diagnosis.
• Some individuals develop ongoing immune reactions even after the bacteria are no longer present.
• Medical attention is important if symptoms include severe abdominal pain or prolonged diarrhea.
  

Conventional Management Options

• Supportive care with fluids and electrolytes
• Antibiotics such as ciprofloxacin, doxycycline, or trimethoprim-sulfamethoxazole in moderate to severe cases
• Rest and avoidance of anti-diarrheal medications unless prescribed
• Pain management and anti-inflammatory support for reactive arthritis if it develops

Functional Medicine Categories Approach

Microbial Balance Support

• Garlic extract (allicin)
• Berberine
• Oregano oil
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after acute symptoms resolve)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Cryptosporidium?
Cryptosporidium is a microscopic parasite that infects the small intestine and causes a diarrheal illness known as cryptosporidiosis. The parasite forms tough outer shells (oocysts) that allow it to survive outside the body and resist many common disinfectants, including chlorine. Because of this, it’s one of the most common waterborne parasites worldwide.

Why is Cryptosporidium Important?
Cryptosporidium infection can cause both short-term and chronic digestive symptoms, especially in individuals with weakened immune systems. Common symptoms include:

• Watery diarrhea
• Abdominal cramps and bloating
• Nausea and vomiting
• Fatigue
• Low-grade fever

In some cases, infection can lead to:

• Dehydration and electrolyte loss
• Malabsorption or nutrient deficiencies
• Prolonged illness in people with weakened immunity (such as those with chronic illness or on immunosuppressants)
• Post-infectious irritable bowel syndrome (IBS)

How Did I Get Cryptosporidium?
Cryptosporidium spreads through the fecal-oral route. Infection occurs when oocysts are swallowed, usually from:

• Drinking or swimming in contaminated water (pools, lakes, rivers, or wells)
• Eating contaminated food
• Touching contaminated surfaces or objects and then touching your mouth
• Contact with infected people or animals (especially young livestock or pets)

The parasite is resistant to chlorine, making it a common cause of outbreaks in swimming pools and recreational water settings.

What Does My Test Show?
Your test detected DNA for Cryptosporidium, indicating that this parasite—or its genetic material—was found in your stool sample. This suggests an active or recent infection. If you are experiencing diarrhea, fatigue, or cramping, it may be contributing to intestinal inflammation or malabsorption.

Why Might Cryptosporidium Cause Symptoms?
After entering the body, Cryptosporidium attaches to the lining of the small intestine, disrupting nutrient absorption and triggering inflammation. This leads to fluid loss and diarrhea. Because the parasite can reproduce in the intestines and release new oocysts, symptoms may persist for weeks if not properly managed.

Important Notes:

• Hydration is critical — even mild cases can cause significant fluid loss.
• The parasite can be contagious for up to two weeks after symptoms stop.
• Individuals with weakened immunity may experience more severe or prolonged illness.
  

Conventional Management Options

• Supportive care with fluids and electrolytes to prevent dehydration
• Prescription antiparasitic medication such as nitazoxanide (Alinia)
• Avoiding swimming pools or food handling until fully recovered
• Rest and gradual reintroduction of bland, nutrient-rich foods

Functional Medicine Categories Approach

Antiparasitic & Microbial Support

• Berberine
• Garlic extract (allicin)
• Oregano oil
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after recovery)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Entamoeba histolytica?
Entamoeba histolytica is a microscopic parasite that infects the large intestine and can cause a disease called amebiasis. It’s more common in regions with poor sanitation or contaminated water sources but can also occur in travelers or individuals exposed to contaminated food or water. While some people may carry the parasite without symptoms, others develop significant intestinal or, in rare cases, liver-related complications.

Why is Entamoeba histolytica Important?
Entamoeba histolytica can cause inflammation and ulceration in the colon, leading to both acute and chronic digestive symptoms. Common signs and symptoms include:

• Abdominal pain and cramping
• Watery or bloody diarrhea
• Fatigue and weakness
• Low-grade fever
• Bloating and gas

In more serious infections, it can lead to:

• Liver abscess (pain in the upper right abdomen)
• Weight loss and malnutrition
• Post-infectious IBS or ongoing digestive sensitivity

How Did I Get Entamoeba histolytica?
The parasite spreads through the fecal-oral route, typically via:

• Drinking contaminated water
• Eating raw or undercooked foods washed with contaminated water
• Poor hand hygiene after bathroom use or diaper changes
• Close contact with infected individuals
• Exposure to contaminated soil or surfaces

Cysts (the dormant form of the parasite) can survive outside the body for long periods, making infection easy in areas with poor sanitation.

What Does My Test Show?
Your test detected DNA for Entamoeba histolytica, meaning this parasite—or its genetic material—was found in your stool sample. This indicates either a current or recent infection. If you are experiencing diarrhea, abdominal pain, or fatigue, this organism may be contributing to inflammation or irritation in your intestines.

Why Might Entamoeba histolytica Cause Symptoms?
Once inside the colon, E. histolytica releases enzymes that break down intestinal tissue, causing ulcers and inflammation. This leads to diarrhea, cramping, and sometimes bleeding. In more severe infections, the parasite can travel through the bloodstream to the liver or other organs, where it forms abscesses.

Important Notes:

• Not all Entamoeba species cause disease — E. dispar and E. moshkovskii are non-pathogenic relatives often detected alongside E. histolytica.
• Medical treatment is essential to fully clear the infection and prevent relapse.
• Practicing good hygiene and using safe drinking water are key to preventing reinfection.
  

Conventional Management Options

• Prescription antiparasitic medications such as metronidazole, tinidazole, or paromomycin
• Hydration and electrolyte replacement during recovery
• Follow-up testing to ensure the parasite has been fully cleared
• Rest and gradual return to a normal diet

Functional Medicine Categories Approach

Antiparasitic & Microbial Support

• Berberine
• Garlic extract (allicin)
• Oregano oil
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after recovery)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Giardia?
Giardia lamblia (also called Giardia intestinalis or Giardia duodenalis) is a microscopic parasite that infects the small intestine and causes a diarrheal illness known as giardiasis. It’s one of the most common intestinal parasites in humans and animals worldwide. The parasite forms cysts that can survive in water, soil, or food for long periods, making it easy to spread—especially in contaminated water sources or through close person-to-person contact.

Why is Giardia Important?
Giardia can cause both acute and chronic digestive symptoms by interfering with nutrient absorption and damaging the intestinal lining. Common symptoms include:

• Watery or greasy diarrhea
• Abdominal cramps and bloating
• Nausea and loss of appetite
• Excessive gas or burping (often with a sulfur smell)
• Fatigue and weakness

If left untreated, Giardia infection can lead to:

• Unintentional weight loss
• Malabsorption of fat and nutrients
• Lactose intolerance after infection
• Post-infectious IBS or chronic gut sensitivity

How Did I Get Giardia?
Giardia spreads through ingestion of cysts (the inactive form of the parasite). Common sources of exposure include:

• Drinking untreated water from lakes, rivers, or wells
• Eating food washed or prepared with contaminated water
• Poor hand hygiene after bathroom use or diaper changes
• Person-to-person contact in households, daycares, or healthcare settings
• Contact with infected pets or livestock

It’s sometimes called “traveler’s diarrhea” or “beaver fever” when contracted from natural water sources during travel or camping.

What Does My Test Show?
Your test detected DNA for Giardia lamblia, meaning this parasite—or its genetic material—was found in your stool sample. This indicates either an active or recent infection. If you are experiencing diarrhea, bloating, or fatigue, Giardia may be disrupting your digestion and nutrient absorption.

Why Might Giardia Cause Symptoms?
Once inside the intestines, Giardia attaches to the intestinal wall using suction-like structures, damaging the mucosal lining and interfering with fat and nutrient absorption. This leads to watery or greasy stools, gas, and bloating. The immune response to Giardia can also inflame the gut and trigger lingering digestive issues even after the infection resolves.

Important Notes:

• Hydration is crucial during recovery due to fluid loss from diarrhea.
• Reinfection can occur easily if sanitation and hygiene practices aren’t followed.
• Some individuals experience post-infectious digestive symptoms that may last several weeks after treatment.
  

Conventional Management Options

• Prescription antiparasitic medications such as metronidazole, tinidazole, or nitazoxanide
• Hydration and electrolyte replacement
• Avoidance of dairy during recovery (temporary lactose intolerance is common)
• Follow-up stool testing to confirm parasite clearance

Functional Medicine Categories Approach

Antiparasitic & Microbial Support

• Berberine
• Garlic extract (allicin)
• Oregano oil
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Zinc carnosine

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after recovery)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Adenovirus 40/41?
Adenovirus types 40 and 41 are viruses that primarily infect the gastrointestinal tract and are known causes of viral gastroenteritis (commonly called “stomach flu”). Unlike other adenoviruses that cause respiratory or eye infections, types 40 and 41 specifically target the intestines. These viruses are common in children but can also affect adults, particularly in close-contact environments like schools, households, or care facilities.

Why is Adenovirus 40/41 Important?
Adenovirus 40/41 infections can cause a range of digestive symptoms that mimic bacterial or parasitic infections. Common symptoms include:

• Watery diarrhea
• Abdominal pain and cramping
• Nausea and vomiting
• Low-grade fever
• Loss of appetite
• Fatigue

In most cases, symptoms last about one to two weeks, but in individuals with weakened immune systems, they can persist longer and cause dehydration or weight loss. Chronic or repeated infections may also contribute to longer-term gut inflammation or post-infectious IBS.

How Did I Get Adenovirus 40/41?
These viruses are spread through the fecal-oral route and are highly contagious. Common transmission sources include:

• Contact with contaminated surfaces, toys, or bathroom fixtures
• Eating food handled by someone infected
• Drinking contaminated water
• Close contact in group settings (schools, daycares, households)

The virus can survive for weeks on surfaces and resist some disinfectants, making hygiene especially important in preventing spread.

What Does My Test Show?
Your test detected DNA for Adenovirus 40/41, meaning viral genetic material was found in your stool sample. This suggests either an active or recent intestinal infection. If you’re experiencing diarrhea, nausea, or cramping, this virus may be contributing to your symptoms.

Why Might Adenovirus 40/41 Cause Symptoms?
After entering the body, the virus infects the cells lining the small intestine, leading to inflammation and fluid secretion. This disrupts normal digestion and absorption, causing diarrhea and dehydration. The immune system’s response to clear the infection can also temporarily affect gut balance and microbiome diversity.

Important Notes:

• Antibiotics are not effective against viruses like Adenovirus.
• Hydration and rest are essential during recovery.
• Good hygiene, including frequent handwashing and surface disinfection, can prevent reinfection and spreading to others.
  

Conventional Management Options

• Supportive care with fluids and electrolytes
• Rest and adequate nutrition during recovery
• Avoidance of anti-diarrheal medications unless recommended by a healthcare provider
• Hospital care for severe dehydration (rare)

Functional Medicine Categories Approach

Viral & Immune Support

• Vitamin C
• Vitamin D
• Zinc
• Olive leaf extract
• Monolaurin

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Antioxidant Support

• N-acetylcysteine (NAC)
• Curcumin
• Quercetin

Microbiome Restoration

• Saccharomyces boulardii
• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after diarrhea resolves)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Norovirus GI/II?
Norovirus is a highly contagious virus that causes acute gastroenteritis — an inflammation of the stomach and intestines that leads to sudden vomiting and diarrhea. The GI (genogroup I) and GII (genogroup II) types are the most common strains that infect humans, with GII being responsible for the majority of outbreaks worldwide. Sometimes called the “winter vomiting virus,” Norovirus spreads easily in group settings like schools, hospitals, restaurants, and cruise ships.

Why is Norovirus Important?
Norovirus is one of the leading causes of foodborne illness globally and can cause rapid-onset, intense digestive symptoms. Common signs and symptoms include:

• Sudden nausea and vomiting
• Watery diarrhea
• Abdominal cramps
• Fever, chills, and muscle aches
• Fatigue and dehydration

While symptoms typically resolve within 1–3 days, they can be more severe in young children, the elderly, and those with weakened immune systems. After recovery, temporary digestive sensitivity or microbiome imbalance can persist.

How Did I Get Norovirus?
Norovirus spreads easily through the fecal-oral route and can survive on surfaces for weeks. Infection occurs from:

• Eating food or drinking water contaminated with the virus
• Touching contaminated surfaces and then touching your mouth
• Close contact with an infected person (especially in households or care settings)
• Aerosolized particles from vomiting that contaminate nearby surfaces or food

Because only a few viral particles are needed to cause infection, outbreaks spread rapidly and are difficult to contain.

What Does My Test Show?
Your test detected DNA for Norovirus GI/II, meaning this virus—or its genetic material—was found in your stool sample. This indicates a recent or active infection. If you’re experiencing diarrhea, nausea, or vomiting, Norovirus is likely a major contributor to those symptoms.

Why Might Norovirus Cause Symptoms?
After entering the digestive tract, Norovirus infects cells in the small intestine, leading to inflammation and impaired nutrient absorption. The immune system’s response to the virus further increases fluid secretion, causing diarrhea and vomiting. Even small amounts of the virus shed in stool can remain infectious, which is why handwashing and cleaning are crucial for preventing spread.

Important Notes:

• Antibiotics do not work against Norovirus since it’s a virus, not a bacteria.
• Hydration is the cornerstone of treatment — electrolyte replacement may be needed for significant fluid loss.
• The virus can continue to shed for up to two weeks after symptoms resolve, even if you feel well.
  

Conventional Management Options

• Supportive care with fluids and electrolytes (oral rehydration solutions are recommended)
• Rest and gradual reintroduction of bland, easy-to-digest foods
• Avoidance of anti-diarrheal medications unless directed by a healthcare provider
• Disinfection of household surfaces with bleach-based cleaners to prevent reinfection

Functional Medicine Categories Approach

Viral & Immune Support

• Vitamin C
• Vitamin D
• Zinc
• Olive leaf extract
• Monolaurin

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Antioxidant Support

• N-acetylcysteine (NAC)
• Curcumin
• Quercetin

Microbiome Restoration

• Saccharomyces boulardii
• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after recovery)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Helicobacter pylori (H. pylori)?
H. pylori is a type of bacteria that can live in the lining of your stomach. It is shaped like a spiral and has special features (like little tails called flagella) that help it move and survive even in the strong acid environment of your stomach. H. pylori is one of the most common infections in the world — about half of all people have it. Many people carry it without symptoms, but for others, it can cause health problems. 

Why is H. pylori Important?
H. pylori can cause irritation and damage to the stomach lining, which may lead to:

• Stomach pain and discomfort
• Acid reflux or heartburn
• Bloating, gas, and nausea
• Bad breath
• Nutrient deficiencies, especially iron and vitamin B12
• More serious problems like stomach ulcers and, over time, a higher risk of stomach cancer in some people It can also cause fatigue, sleep problems, and may contribute to histamine intolerance (reactions like flushing, hives, or congestion after eating certain foods). 

How Did I Get H. pylori?
H. pylori is usually picked up during childhood and can stay in your body for years. It spreads through:

• Eating or drinking contaminated food or water
• Close contact with family members or others (sharing utensils, cups, etc.)
• Poor hygiene practices (like not washing hands well)

It’s more common in areas where clean water and sanitation are harder to maintain.

What Does My Test Show?
Your test results detected H. pylori DNA in your stool sample. This means the bacteria are present in your digestive system and may be contributing to your symptoms. Sometimes the test also looks for "virulence factors" — special traits that can make the bacteria more aggressive or damaging. If these traits are found, it can mean a higher risk for more serious stomach problems, but it doesn’t guarantee you will develop them. It just helps your healthcare team understand your personal situation better.

Why Might H. pylori Cause Symptoms?
H. pylori survives by producing a special enzyme (called urease) that protects it from stomach acid. Over time, this battle inside your stomach can cause:

• Inflammation (irritation of the stomach lining)
• Damage to the protective layer of the stomach
• Greater sensitivity to foods or digestive upset
• Nutrient absorption problems (especially with iron and B vitamins)
• In some cases, if not managed properly, it can lead to ulcers (painful sores) or more serious health concerns.

Important Notes: Some forms of H. pylori can go "dormant" (called coccoid forms) and hide, making them harder to detect and treat fully. Reinfection can happen if hygiene practices aren’t carefully followed after treatment. It’s possible that other family members may also carry H. pylori without knowing it.

Conventional Management Options:

• Bismuth Subsalicylate + Metronidazole + Tetracycline + PPI
• Clarithromycin + Amoxicillin + PPI
• Clarithromycin + Amoxicillin + Metronidazole + PPI

Functional Medicine Categories Approach: 

Biofilm Disruption

• NAC
• Berberine
• Linolenic Acid

Urease Inhibition

• Green Tea
• Cranberry Juice
• DGL Licorice

Adhesion Inhibition

• Zinc Carnosine
• DGL
• Mastic Gum

Immune + Mitochondria + Inflammation Support

• Saccharomyces boulardii
• Probiotics
• Vitamin C
• Vitamin D

Gastric Lining Support

• L-glutamine
• Aloe Vera
• Marshmallow root
• Slippery Elm

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Virulence Factor, babA?
The babA gene (blood group antigen-binding adhesin) is one of Helicobacter pylori’s virulence factors — special traits that make certain strains more aggressive or damaging. The babA protein allows H. pylori to attach more tightly to the cells lining the stomach by binding to a molecule called the Lewis b antigen on gastric epithelial cells. This strong attachment helps the bacteria survive longer, resist being flushed out by stomach acid, and maintain chronic infection.

Why is babA Important?
When H. pylori carries the babA gene, it’s often linked to greater inflammation and an increased risk of more serious stomach conditions. People infected with babA-positive strains may experience:

• More intense stomach pain or burning
• Higher likelihood of gastritis or ulcers
• Increased risk for intestinal metaplasia and, in some cases, gastric cancer

This doesn’t mean everyone with the babA gene will develop complications — it simply indicates a strain that has more potential to damage the stomach lining and persist long term if not addressed.

How Did I Get H. pylori with babA?
The babA virulence factor is part of the bacterial strain you were exposed to — it isn’t acquired separately. Most people contract H. pylori in childhood through close contact with family members, contaminated food, or unclean water. The presence of babA means your particular strain has a genetic trait that makes it more adhesive and resilient in the stomach environment.

What Does My Test Show?
Your test detected DNA for H. pylori and the babA virulence factor. This means the bacteria in your stomach can strongly attach to stomach cells, potentially causing more inflammation or irritation. It helps explain why some people have more severe or persistent symptoms even with similar H. pylori levels.

Why Might babA Cause Symptoms?
The babA adhesin helps H. pylori anchor tightly to the stomach lining, allowing it to resist stomach acid and immune defense. This close contact increases local inflammation, weakens the mucosal barrier, and leads to greater irritation and discomfort. Over time, this ongoing inflammation may contribute to ulcer formation or worsen acid-related symptoms.

Important Notes:

• The presence of babA doesn’t guarantee disease, but it increases the potential for chronic irritation and ulceration.
• Managing inflammation and supporting the gastric mucosa are especially important in babA-positive cases.
• A comprehensive approach — addressing the bacteria, biofilm, and stomach environment — offers the best chance for full resolution.
  

Conventional Management Options

• Standard antibiotic therapy for H. pylori eradication (e.g., bismuth quadruple therapy or clarithromycin-based therapy)
• Proton pump inhibitors (PPIs) or H2 blockers to reduce stomach acid
• Follow-up testing to ensure eradication of H. pylori
• Avoiding stomach irritants such as alcohol, caffeine, and NSAIDs

Functional Medicine Categories Approach

Biofilm Disruption

• N-acetylcysteine (NAC)
• Berberine
• Linolenic acid

Urease & Adhesion Inhibition

• Green tea extract
• Zinc carnosine
• Mastic gum
• DGL licorice

Immune + Mitochondrial + Inflammation Support

• Saccharomyces boulardii
• Vitamin D
• Vitamin C
• Probiotics

Gastric Lining Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm 

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Virulence Factor, cagA?
The cagA gene (cytotoxin-associated gene A) is one of the most clinically significant virulence factors in Helicobacter pylori. When present, it indicates a more aggressive strain of the bacteria. H. pylori strains that carry cagA inject this protein into stomach cells using a specialized system (type IV secretion system). Once inside, the CagA protein disrupts normal cell signaling, leading to increased inflammation, tissue damage, and in some cases, precancerous cellular changes.

Why is cagA Important?
The presence of cagA is strongly associated with more severe gastric inflammation and higher risk of complications. Infection with cagA-positive H. pylori strains has been linked to:

• Greater risk of peptic ulcer disease
• Chronic gastritis and stomach lining erosion
• Increased risk of gastric cancer and MALT lymphoma, and more pronounced acid reflux and discomfort symptoms.

However, not everyone with cagA develops complications — it simply identifies a strain that’s more inflammatory and damaging to stomach cells.

How Did I Get H. pylori with cagA?
You likely acquired H. pylori through contaminated food, water, or close personal contact during childhood. The cagA gene is a built-in feature of the bacterial strain you were exposed to — it’s not something acquired later. This particular strain uses cagA to inject toxins into stomach cells, which worsens irritation and prolongs infection.

What Does My Test Show?
Your test detected DNA for H. pylori and its virulence factor cagA, meaning this infection involves a strain capable of producing the CagA toxin. This suggests a higher potential for inflammation and gastric damage, which may explain persistent symptoms such as pain, bloating, or reflux. It’s a key marker used by clinicians to gauge infection severity.

Why Might cagA Cause Symptoms?
When H. pylori releases the CagA protein into the stomach lining, it interferes with normal cell repair and immune function. This leads to stronger inflammation, more oxidative stress, and weakening of the stomach’s protective barrier. Over time, these effects increase susceptibility to ulcers, gastritis, and potentially precancerous changes if the infection remains untreated.

Important Notes:

• cagA positivity means greater need for comprehensive treatment and gut lining repair.
• Reducing inflammation and supporting mucosal healing are key post-eradication steps.
• Regular follow-up with a provider is recommended, especially if there’s a family history of ulcers or stomach cancer.
  

Conventional Management Options

• Combination antibiotic therapy (such as bismuth quadruple therapy or  clarithromycin-based regimens)
• Proton pump inhibitors (PPIs) or H2 blockers to lower stomach acid and support healing
• Testing for eradication after treatment
• Avoiding stomach irritants like NSAIDs, alcohol, and smoking 

Functional Medicine Categories Approach

Biofilm Disruption

• N-acetylcysteine (NAC)
• Berberine
• Linolenic acid

Urease & Adhesion Inhibition

• Green tea extract
• Zinc carnosine
• Mastic gum
• DGL licorice

Anti-Inflammatory & Antioxidant Support

• Curcumin
• Quercetin
• Vitamin C
• Vitamin D

Immune & Mitochondrial Support

• Saccharomyces boulardii
• Probiotics
• Omega-3 fatty acids

Gastric Lining Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Virulence Factor, dupA?
The dupA gene (duodenal ulcer–promoting gene A) is a virulence factor found in certain strains of Helicobacter pylori. It’s associated with an increased risk of inflammation in the upper digestive tract, particularly in the duodenum (the first part of the small intestine). The dupA protein contributes to chronic irritation and acid-related damage, which may raise the likelihood of developing duodenal ulcers.

Why is dupA Important?
When H. pylori carries the dupA gene, it is often linked to a stronger inflammatory response in the stomach and duodenum. Individuals with dupA-positive strains may experience:

• Increased stomach pain or burning (especially when hungry or at night)
• Higher likelihood of duodenal ulcer formation
• Bloating, belching, and early fullness
• Reflux-like symptoms or nausea

Interestingly, some studies suggest that dupA may reduce the risk of gastric cancer compared to other virulent strains like cagA, though it still promotes ulcer development.

How Did I Get H. pylori with dupA?
The dupA gene is part of the genetic makeup of the H. pylori strain you were exposed to. Infection typically occurs during childhood through contaminated food, water, or close household contact. The dupA factor determines how your specific strain interacts with stomach and intestinal tissues, influencing the type of symptoms you experience.

What Does My Test Show?
Your test detected DNA for H. pylori and its virulence factor dupA, meaning this bacterial strain carries the gene associated with duodenal inflammation and ulcer risk. This helps explain symptoms such as upper abdominal pain, reflux, or bloating, and can guide both conventional and functional treatment strategies.

Why Might dupA Cause Symptoms?
The dupA gene increases the ability of H. pylori to cause inflammation in the stomach and small intestine. It stimulates the immune system and acid-producing cells, leading to excess acid exposure and mucosal damage. This process contributes to irritation, ulcer formation, and discomfort.

Important Notes:

• dupA positivity indicates a strain that tends to cause more duodenal (rather than gastric) inflammation.
• Eradication of H. pylori combined with mucosal repair typically results in full recovery.
• Ongoing gut barrier and anti-inflammatory support are important even after treatment.
  

Conventional Management Options

• Combination antibiotic therapy for H. pylori (e.g., bismuth-based quadruple therapy or clarithromycin triple therapy)
• Proton pump inhibitors (PPIs) to reduce stomach acid and promote ulcer healing
• Follow-up testing to confirm eradication
• Avoiding irritants such as caffeine, alcohol, and NSAIDs

Functional Medicine Categories Approach

Biofilm Disruption

• N-acetylcysteine (NAC)
• Berberine
• Linolenic acid

Urease & Adhesion Inhibition

• Green tea extract
• Zinc carnosine
• Mastic gum
• DGL licorice

Anti-Inflammatory & Immune Support

• Curcumin
• Quercetin
• Saccharomyces boulardii
• Vitamin D

Gastric & Duodenal Lining Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after recovery)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Virulence Factor, iceA?
The iceA gene (induced by contact with epithelium A) is a virulence factor found in certain strains of Helicobacter pylori. This gene becomes active when the bacteria come into direct contact with the stomach lining (epithelial cells). Although research is still evolving, iceA-positive strains are commonly associated with higher levels of stomach inflammation and a greater likelihood of developing peptic ulcers, particularly in the antrum (lower part) of the stomach.

Why is iceA Important?
The presence of the iceA gene indicates a strain of H. pylori that is more likely to cause irritation and ulcer formation. People infected with iceA-positive strains may experience:

• Burning or aching stomach pain (especially between meals or at night)
• Bloating and fullness after eating
• Heartburn or nausea
• Loss of appetite or early satiety

Although iceA is not as strongly linked to cancer risk as cagA, it has been correlated with more severe local inflammation and tissue damage, making it a useful marker for understanding symptom severity.

How Did I Get H. pylori with iceA?
You likely acquired H. pylori during childhood through contaminated food, water, or close household contact. The iceA gene is part of the bacterial strain itself — meaning your particular strain activates stronger inflammatory responses when it attaches to stomach tissue.

What Does My Test Show?
Your test detected DNA for H. pylori and its virulence factor iceA. This means your strain of H. pylori has genetic potential to trigger increased stomach inflammation and possibly ulcer formation. If you’re experiencing symptoms such as burning pain, bloating, or nausea, this virulence factor may be contributing to those effects.

Why Might iceA Cause Symptoms?
When H. pylori expressing iceA attaches to the stomach lining, it triggers the immune system to release inflammatory chemicals and enzymes that damage mucosal tissue. This inflammation weakens the protective barrier of the stomach, allowing acid to further irritate the tissue, resulting in discomfort, ulcers, or reflux symptoms.

Important Notes:

• The iceA gene contributes primarily to ulcer-type symptoms rather than gastric cancer risk.
• Managing inflammation and promoting mucosal healing are key priorities post-eradication.
• Comprehensive testing for multiple virulence factors helps identify your individual risk profile.
  

Conventional Management Options

• Combination antibiotic therapy (bismuth quadruple therapy or clarithromycin-based regimens)
• Proton pump inhibitors (PPIs) or H2 blockers to reduce stomach acid
• Follow-up stool or breath test to confirm eradication
• Avoiding irritants like caffeine, alcohol, and NSAIDs during treatment

Functional Medicine Categories Approach

Biofilm Disruption

• N-acetylcysteine (NAC)
• Berberine
• Linolenic acid

Urease & Adhesion Inhibition

• Green tea extract
• Zinc carnosine
• Mastic gum
• DGL licorice

Anti-Inflammatory & Immune Support

• Curcumin
• Quercetin
• Saccharomyces boulardii
• Vitamin D

Gastric Lining Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Microbiome Restoration

• Probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after treatment)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Virulence Factor, oipA?
The oipA gene (outer inflammatory protein A) is a virulence factor found in certain strains of Helicobacter pylori. This gene codes for a surface protein that helps the bacteria adhere more effectively to stomach cells and promotes the release of inflammatory molecules in the gastric mucosa. When active, oipA increases the immune response and tissue inflammation, often leading to stronger and more persistent gastric symptoms.

Why is oipA Important?
The presence of the oipA gene is associated with more aggressive forms of H. pylori infection. People carrying oipA-positive strains may experience:

• More pronounced stomach pain or burning
• Greater risk of chronic gastritis or duodenitis
• Higher likelihood of developing peptic ulcers
• Bloating, reflux, and post-meal discomfort

When combined with other virulence factors like cagA or babA, oipA can amplify inflammation and tissue injury, increasing the risk of long-term complications if not addressed.

How Did I Get H. pylori with oipA?
You likely acquired H. pylori in childhood through contaminated food, water, or close contact with infected individuals. The oipA virulence factor is part of your particular bacterial strain’s genetics — meaning your strain is more capable of adhering to stomach cells and triggering inflammation once infection occurs.

What Does My Test Show?
Your test detected DNA for H. pylori and its virulence factor oipA. This result indicates that your infection involves a strain with a higher potential to attach to and inflame the stomach lining. This can help explain symptoms like persistent gastritis, upper abdominal pain, reflux, or nausea.

Why Might oipA Cause Symptoms?
The oipA protein promotes inflammation by stimulating stomach cells to release cytokines (chemical messengers of the immune system). This leads to swelling, irritation, and erosion of the mucosal barrier that protects the stomach wall. The result can be chronic gastritis, acid sensitivity, or ulcer formation if the infection persists over time.

Important Notes:

• The oipA gene contributes to stronger inflammation and increased ulcer risk but does not necessarily mean cancer risk on its own.
• Addressing bacterial eradication, reducing inflammation, and rebuilding the stomach lining are key to full recovery.
• A multi-faceted approach works best when this virulence factor is present.
  

Conventional Management Options

• Combination antibiotic therapy (e.g., bismuth quadruple therapy or clarithromycin-based regimens)
• Proton pump inhibitors (PPIs) or H2 blockers to reduce acid and promote healing
• Testing for eradication after treatment completion
• Avoiding alcohol, NSAIDs, and smoking to reduce mucosal damage

Functional Medicine Categories Approach

Biofilm Disruption

• N-acetylcysteine (NAC)
• Berberine
• Linolenic acid

Urease & Adhesion Inhibition

• Green tea extract
• Zinc carnosine
• Mastic gum
• DGL licorice

Anti-Inflammatory & Immune Support

• Curcumin
• Quercetin
• Saccharomyces boulardii
• Vitamin D

Gastric Lining Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after treatment)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Virulence Factor, vacA?
The vacA gene (vacuolating cytotoxin A) is one of the most studied virulence factors of Helicobacter pylori. It produces a toxin that can damage stomach lining cells by creating tiny “vacuoles,” or holes, inside them. This weakens the protective mucosal barrier of the stomach and makes it more vulnerable to acid injury, inflammation, and infection-related complications. Almost all H. pylori strains have the vacA gene, but some forms (genetic subtypes) are more active and damaging than others.

Why is vacA Important?
The vacA virulence factor is linked to several digestive conditions and influences how severe H. pylori infection may become. People infected with vacA-positive strains may experience:

• Chronic gastritis or stomach irritation
• Peptic ulcers (particularly in the stomach or duodenum)
• Nausea, bloating, or acid reflux
• Loss of appetite or unintentional weight changes

More active forms of vacA are also associated with a higher risk of gastric ulcers and, in some cases, gastric cancer, especially when combined with other virulence factors like cagA and babA.

How Did I Get H. pylori with vacA?
You likely acquired H. pylori during childhood through contaminated food, water, or close contact with family members or others who were infected. The vacA gene is part of the bacterial strain you were exposed to. This strain’s ability to produce the VacA toxin determines how much irritation or damage occurs in the stomach lining.

What Does My Test Show?
Your test detected DNA for H. pylori and its virulence factor vacA, which means your bacterial strain has the potential to produce the VacA toxin. This can help explain persistent stomach irritation, reflux, or ulcer-type symptoms, especially if inflammation remains high or the bacteria have been present for a long time.

Why Might vacA Cause Symptoms?
The VacA toxin produced by this gene damages the cells of the stomach lining, disrupts mucus production, and alters immune cell function. This weakens the protective barrier of the stomach, making it more sensitive to acid and leading to inflammation, ulcers, or delayed healing. VacA can also suppress certain immune responses, allowing H. pylori to persist and cause ongoing irritation.

Important Notes:

• The vacA virulence factor is one of the main contributors to ulcer development and chronic inflammation.
• Eradicating the bacteria and rebuilding the stomach lining are key to long-term recovery.
• Reducing acid irritation through diet, stress management, and targeted supplementation can accelerate healing.
  

Conventional Management Options

• Combination antibiotic therapy (such as bismuth quadruple therapy or clarithromycin-based regimens)
• Proton pump inhibitors (PPIs) or H2 blockers to reduce stomach acid and allow healing
• Testing for eradication after therapy
• Avoidance of NSAIDs, alcohol, and smoking to reduce additional gastric irritation

Functional Medicine Categories Approach

Biofilm Disruption

• N-acetylcysteine (NAC)
• Berberine
• Linolenic acid

Toxin & Adhesion Inhibition

• Green tea extract
• Zinc carnosine
• Mastic gum
• DGL licorice

Anti-Inflammatory & Immune Support

• Curcumin
• Quercetin
• Vitamin C
• Vitamin D
• Saccharomyces boulardii

Gastric Lining Repair

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (added gradually after eradication)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Virulence Factor, virB?
The virB gene is part of Helicobacter pylori’s type IV secretion system—a complex structure the bacteria use to inject toxins (like CagA) directly into stomach lining cells. This system functions like a molecular syringe, allowing H. pylori to communicate with and manipulate gastric cells. The virB gene encodes one of the essential components of this secretion system, enabling the delivery of virulence proteins that drive inflammation and cellular damage.

Why is virB Important?
The presence of virB indicates a more virulent strain of H. pylori that is capable of causing stronger immune activation and tissue injury. Individuals with virB-positive strains may experience:

• Persistent gastritis or burning stomach pain
• Higher risk of peptic ulcers
• Increased inflammation and oxidative stress
• Greater potential for gastric tissue changes over time

When combined with other virulence factors like cagA, vacA, and oipA, the virB gene enhances bacterial survival and contributes to chronic irritation and delayed healing.

How Did I Get H. pylori with virB?
The virB gene is part of the specific H. pylori strain you were exposed to, not something acquired separately. Infection typically occurs in childhood through contaminated food, water, or close contact with an infected person. The presence of virB means your strain has the machinery needed to inject inflammatory proteins directly into your stomach cells, leading to more persistent inflammation.

What Does My Test Show?
Your test detected DNA for H. pylori and its virulence factor virB, suggesting your infection involves a strain capable of producing and delivering toxins through the type IV secretion system. This indicates a more aggressive strain that may cause stronger inflammation, irritation, and slower tissue healing.

Why Might virB Cause Symptoms?
The virB gene contributes to stomach irritation by enabling H. pylori to insert proteins into stomach lining cells, disrupting their normal function. This process increases inflammation, weakens the mucosal barrier, and damages the tissue that protects your stomach from acid. Over time, this may cause pain, burning, bloating, or reflux-like symptoms.

Important Notes:

• virB positivity often appears alongside cagA, amplifying its inflammatory effects.
• The infection can persist for years without treatment, so confirming eradication is important.
• Gut barrier support after eradication is essential for healing and symptom relief.
  

Conventional Management Options

• Combination antibiotic therapy (such as bismuth quadruple or clarithromycin-based therapy)
• Proton pump inhibitors (PPIs) or H2 blockers to reduce acid and promote repair
• Follow-up testing to confirm H. pylori clearance
• Avoiding stomach irritants such as alcohol, caffeine, and NSAIDs

Functional Medicine Categories Approach

Biofilm Disruption

• N-acetylcysteine (NAC)
• Berberine
• Linolenic acid

Toxin & Adhesion Inhibition

• Green tea extract
• Zinc carnosine
• Mastic gum
• DGL licorice

Anti-Inflammatory & Immune Support

• Curcumin
• Quercetin
• Saccharomyces boulardii
• Vitamin C
• Vitamin D

Gastric Lining Repair

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after recovery)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Virulence Factor, virD?
The virD gene is another key component of Helicobacter pylori’s type IV secretion system, a molecular transport mechanism the bacteria use to inject virulence proteins (like CagA) into stomach cells. This system allows H. pylori to directly interfere with normal gastric cell functions, increase inflammation, and promote long-term survival in the stomach’s harsh environment. The virD gene works closely with virB to form this secretion structure, making it an important marker of a highly active and potentially more damaging strain.

Why is virD Important?
The virD virulence factor contributes to inflammation, tissue injury, and ulcer risk. When present, it typically signals a more aggressive H. pylori infection capable of producing stronger immune and inflammatory responses. Individuals with virD-positive strains may experience:

• Persistent or burning stomach pain
• Nausea and acid reflux
• Bloating and post-meal fullness
• Higher risk of ulcers or chronic gastritis

When virD appears alongside other virulence factors like cagA, vacA, or oipA, it compounds inflammation and tissue irritation, leading to longer-lasting or more severe symptoms.

How Did I Get H. pylori with virD?
The virD gene is part of the genetic makeup of the H. pylori strain you were exposed to — it’s not something acquired separately. Infection typically happens during childhood via contaminated food, water, or close personal contact. The presence of virD means your strain is capable of delivering virulence proteins directly into stomach cells, heightening inflammation and irritation.

What Does My Test Show?
Your test detected DNA for H. pylori and its virulence factor virD, which means your bacterial strain contains the genes that help construct the type IV secretion system. This allows the bacteria to inject toxins into stomach lining cells, causing inflammation and weakening of the protective mucosal barrier. This result suggests a more virulent strain that may contribute to gastritis, reflux, or ulcer-type symptoms.

Why Might virD Cause Symptoms?
The virD gene helps H. pylori manipulate stomach cells and immune responses through the release of inflammatory proteins. This disrupts cell function, increases acid sensitivity, and damages tissue over time. The result can be chronic inflammation, ulceration, and persistent digestive discomfort even in the absence of acute infection.

Important Notes:

• The virD gene usually works in combination with virB as part of the same virulence machinery.
• Eradication of the bacteria and restoration of the stomach lining are essential steps to healing.
• Gut barrier and microbiome support after treatment reduce the risk of symptom recurrence. 

Conventional Management Options

• Combination antibiotic therapy (bismuth quadruple therapy or clarithromycin-based triple therapy)
• Proton pump inhibitors (PPIs) or H2 blockers to reduce acid and promote tissue healing
• Follow-up testing to confirm eradication
• Avoiding alcohol, NSAIDs, and smoking to minimize mucosal irritation

Functional Medicine Categories Approach

Biofilm Disruption

• N-acetylcysteine (NAC)
• Berberine
• Linolenic acid

Toxin & Adhesion Inhibition

• Green tea extract
• Zinc carnosine
• Mastic gum
• DGL licorice

Anti-Inflammatory & Immune Support

• Curcumin
• Quercetin
• Saccharomyces boulardii
• Vitamin C
• Vitamin D

Gastric Lining Repair

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (introduced gradually after recovery)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Bacteroides fragilis?
Bacteroides fragilis is a type of beneficial bacteria that naturally lives in the large intestine. It plays an important role in maintaining gut health by helping to break down complex carbohydrates, support immune function, and regulate inflammation. Although it is a normal part of a healthy microbiome, balance is key — both low and high levels of B. fragilis can affect digestive health.

Why is Bacteroides fragilis Important?
Bacteroides fragilis supports several essential gut functions:

• Aids in digestion of fiber and carbohydrates, producing short-chain fatty acids (SCFAs) like butyrate that nourish colon cells.
• Modulates immune activity, helping to keep inflammation in check.
• Maintains the intestinal barrier and prevents overgrowth of harmful bacteria.
  

However, imbalances can contribute to symptoms or health issues:

• Low levels may weaken mucosal defense, reduce SCFA production, and promote inflammation or loose stools.
• High levels (overgrowth) may indicate dysbiosis and can produce compounds that irritate the intestinal lining, leading to gas, bloating, or discomfort.
  

How Did My Levels Become Imbalanced?
Shifts in B. fragilis abundance can occur due to:

• Antibiotic or antimicrobial use
• Low-fiber or high-fat diets
• Chronic stress or inflammation
• Gut infections or foodborne illness
• Reduced microbial diversity from limited dietary variety
  

What Does My Test Show?
Your GI-MAP results provide insight into whether Bacteroides fragilis is within a healthy range.

• Normal levels indicate a balanced gut ecosystem.
• Low levels may suggest weakened digestion, reduced mucosal protection, or lack of dietary fiber.
• High levels may reflect bacterial imbalance or an environment that favors opportunistic overgrowth.
  

Why Might Bacteroides fragilis Affect Symptoms?
As part of the gut’s normal flora, B. fragilis influences inflammation and immune signaling. When it’s balanced, it supports tolerance and reduces reactivity in the gut. When elevated, it may release inflammatory byproducts like lipopolysaccharides (LPS), which can contribute to bloating, cramping, or systemic inflammation.

Important Notes:

• B. fragilis is normally beneficial but must remain in proportion to other gut species.
• Dietary fiber, prebiotics, and a diverse plant-based diet help maintain healthy levels.
• Overgrowth typically improves when underlying dysbiosis or inflammation is addressed.
  

Conventional Management Options

• Balanced diet rich in soluble and insoluble fiber
• Addressing underlying infections or inflammation
• Antibiotics or targeted antimicrobials only if clinically indicated for overgrowth
• Probiotic therapy under medical supervision

Functional Medicine Categories Approach

Microbial Balance Support

• Berberine
• Oregano oil (short-term, only if elevated)
• Garlic extract (allicin)
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Aloe vera
• Marshmallow root
• Slippery elm

Prebiotic & Fiber Support

• Partially hydrolyzed guar gum (PHGG)
• Inulin or GOS (as tolerated)
• Flaxseed and chia seed
• Resistant starches (green banana flour, cooked and cooled potatoes)

Anti-Inflammatory & Immune Modulation

• Vitamin D
• Zinc carnosine
• Curcumin

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus, Bifidobacterium, and spore-based species)
• High-fiber, plant-diverse diet (30+ plant foods per week goal)

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Bifidobacterium spp.?
Bifidobacterium species are among the most beneficial and well-studied bacteria in the human gut. They are some of the first microbes to colonize the intestines after birth and play a key role in digestion, immune regulation, and gut barrier integrity. Found primarily in the large intestine, these bacteria help ferment dietary fibers into beneficial short-chain fatty acids (SCFAs), such as acetate and butyrate, which nourish intestinal cells and reduce inflammation.

Why is Bifidobacterium Important?
Healthy levels of Bifidobacterium are associated with optimal gut and immune health. They help to:

• Support healthy digestion and regular bowel movements
• Maintain gut barrier function and prevent “leaky gut”
• Reduce inflammation and modulate immune activity
• Protect against overgrowth of pathogens like E. coli and Clostridium species
• Produce B vitamins and beneficial fatty acids that support metabolism
  

When Bifidobacterium levels are low, you may experience:

• Constipation or irregular bowel habits
• Bloating and gas after meals
• Increased food sensitivities or inflammation
• Reduced resilience to infections or antibiotic side effects
  

How Did My Levels Become Imbalanced?
Low Bifidobacterium levels can result from:

• Frequent antibiotic or antimicrobial use
• Diets low in fiber and plant diversity
• High stress or chronic inflammation
• Inadequate probiotic intake
• Aging or reduced microbial diversity
  

Conversely, high levels are rare and usually not concerning unless accompanied by other signs of dysbiosis.

What Does My Test Show?
Your GI-MAP results reveal whether Bifidobacterium species are present in a healthy range.

• Normal levels suggest balanced digestion, immune function, and mucosal health.
• Low levels may indicate poor fermentation of dietary fibers and reduced gut resilience.
• High levels (uncommon) may occur during probiotic use or in response to shifts in other microbial groups. 

Why Might Bifidobacterium Affect Symptoms?
When Bifidobacterium is low, the gut may produce fewer SCFAs, reducing anti-inflammatory activity and compromising mucosal protection. This can lead to irregular stools, bloating, or immune imbalance. Replenishing Bifidobacterium through diet and targeted supplementation often helps restore digestive comfort and overall gut stability.

Important Notes:

• Bifidobacterium species are crucial for both gut and systemic immune health.
• A diverse, fiber-rich diet is the best long-term way to support healthy levels.
• Supplementation is often beneficial, especially after antibiotics or gut infections.
  

Conventional Management Options

• Increased intake of dietary fiber and prebiotic foods (onions, garlic, leeks, asparagus, oats)
• Consideration of probiotic supplements containing Bifidobacterium breve, B. longum, B. bifidum, or B. infantis
• Addressing underlying dysbiosis or inflammation with diet and lifestyle modifications
• Hydration and regular meal patterns to support healthy motility

Functional Medicine Categories Approach

Microbiome Restoration

• Probiotic formulas containing Bifidobacterium breve, B. longum, B. bifidum, B. infantis
• Prebiotic support (inulin, GOS, PHGG, or resistant starches)

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera

Anti-Inflammatory & Immune Support

• Vitamin D
• Curcumin
• Omega-3 fatty acids

Lifestyle & Dietary Support

• High-fiber diet (30+ different plants per week)
• Fermented foods (as tolerated): kefir, sauerkraut, kimchi, coconut yogurt
• Stress reduction, quality sleep, and regular physical activity to support microbiome balance

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Enterococcus spp.?
Enterococcus species are a group of bacteria that are part of the normal flora of the human intestines. The most common species found in the gut are Enterococcus faecalis and Enterococcus faecium. In healthy amounts, they help with digestion and nutrient processing; however, when overgrown, these same bacteria can act as opportunistic pathogens and contribute to gut imbalance or infection.

Why is Enterococcus Important?
In balanced amounts, Enterococcus species play beneficial roles such as:

• Assisting in the breakdown of complex carbohydrates and proteins
• Contributing to lactic acid production, which helps maintain a healthy intestinal pH
• Supporting microbial diversity by competing with harmful bacteria
  

However, overgrowth or translocation (movement outside the gut) can create problems. Imbalances in Enterococcus may lead to:

• Gas, bloating, or abdominal discomfort
• Small intestinal bacterial overgrowth (SIBO)–like symptoms
• Increased intestinal permeability (“leaky gut”)
• Urinary tract or bloodstream infections in severe cases (especially in immunocompromised individuals)
  

How Did My Levels Become Imbalanced?
Changes in Enterococcus levels can result from:

• Frequent antibiotic use or antimicrobial overuse
• Diets high in sugar or processed foods
• Chronic inflammation or stress
• Disruption of normal gut flora from illness or medication
• Hospital exposure (for E. faecalis and E. faecium, which are more resistant strains)
  

What Does My Test Show?
Your GI-MAP results indicate whether Enterococcus species are within a healthy range.

• Normal levels support digestion and microbial balance.
• Elevated levels may suggest dysbiosis, SIBO, or intestinal inflammation.
• Low levels are uncommon but may occur after antibiotic use or gut-cleansing therapies.
  

Why Might Enterococcus Affect Symptoms?
When Enterococcus species are overrepresented, they can ferment carbohydrates excessively, producing gas and contributing to bloating or discomfort. They may also form biofilms and compete with beneficial bacteria, reducing overall microbiome diversity. If they translocate beyond the intestines, they can cause more serious infections.

Important Notes:

• Enterococcus is part of normal gut flora but becomes problematic in excess.
• Addressing the underlying cause of imbalance (antibiotic exposure, diet, inflammation) is key.
• Gut barrier repair helps prevent opportunistic behavior from these bacteria.
  

Conventional Management Options

• Addressing underlying dysbiosis or infection with targeted antimicrobials (if clinically indicated)
• Hydration and fiber intake to support motility and healthy flora balance
• Antibiotics (only if pathogenic overgrowth or infection confirmed)
• Monitoring for recurrent symptoms if levels remain elevated

Functional Medicine Categories Approach

Microbial Balance Support

• Berberine
• Oregano oil
• Garlic extract (allicin)
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera
• Marshmallow root

Anti-Inflammatory & Immune Support

• Vitamin D
• Curcumin
• Saccharomyces boulardii

Microbiome Restoration

• Probiotics containing Lactobacillus and Bifidobacterium species (to rebalance flora)
• Prebiotic fibers (introduced slowly to avoid gas and bloating)

Lifestyle & Dietary Support

• Emphasize a whole-food, high-fiber diet with minimal refined sugar
• Avoid unnecessary antibiotics or antimicrobial herbs long-term
• Support regular bowel movements to prevent overgrowth

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Escherichia spp.?
Escherichia species — most commonly Escherichia coli (E. coli) — are a diverse group of bacteria that naturally inhabit the human intestines. Many strains are beneficial and essential for normal digestion, vitamin production, and immune regulation. However, certain strains can become opportunistic or pathogenic, leading to inflammation, infection, or gastrointestinal symptoms.

Why is Escherichia Important?
In healthy amounts, E. coli plays several positive roles in the gut:

• Aids in digestion and nutrient absorption
• Produces vitamin K and some B vitamins
• Competes with harmful bacteria to maintain balance
• Helps regulate intestinal pH and protect against infection
  

However, imbalance or infection with pathogenic strains can cause:

• Gas, bloating, and abdominal pain
• Diarrhea or constipation
• Urinary tract infections (UTIs) if translocated
• Post-infectious IBS or inflammation after acute infection
  

How Did My Levels Become Imbalanced?
Disruption in Escherichia levels can occur due to:

• Antibiotic use or overuse of antimicrobial herbs
• Poor water or food sanitation (exposure to pathogenic strains)
• Diets low in fiber and plant diversity
• Chronic inflammation or low stomach acid
• Stress or compromised immune function
  

What Does My Test Show?
Your GI-MAP results reveal whether Escherichia species are within a normal range.

• Normal levels indicate balanced colon function and a healthy microbiome.
• Low levels may suggest reduced microbial diversity, possibly after antibiotic use.
• High levels could indicate bacterial overgrowth or colonization by more inflammatory strains.
  

If the test identifies specific pathogenic E. coli subtypes (like Enteropathogenic E. coli or Shiga-toxin producing E. coli), these are handled separately in the “Bacterial Pathogens” section.

Why Might Escherichia Affect Symptoms?
When E. coli is too low, the gut may lose some protective benefits — including reduced immune signaling and impaired vitamin production. When elevated, it can release endotoxins such as lipopolysaccharides (LPS), triggering inflammation, bloating, or diarrhea. Pathogenic forms may also damage intestinal cells directly, increasing permeability and immune activation.

Important Notes:

• Most E. coli species are beneficial, but certain strains can cause harm.
• Healthy E. coli levels help stabilize the gut environment and support overall digestion.
• Balance is key — treatment aims to restore diversity, not eliminate E. coli entirely.
  

Conventional Management Options

• Hydration and supportive care for mild digestive symptoms
• Targeted antibiotics (only when pathogenic strains are confirmed)
• Dietary changes to restore microbial balance
• Probiotic therapy under medical supervision

Functional Medicine Categories Approach

Microbial Balance Support (for overgrowth)

• Berberine
• Oregano oil
• Garlic extract (allicin)
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera
• Marshmallow root

Anti-Inflammatory & Immune Support

• Curcumin
• Vitamin D
• Saccharomyces boulardii

Microbiome Restoration (for low levels or recovery)

• Multi-strain probiotics containing E. coli Nissle 1917 (clinically studied beneficial strain)
• Lactobacillus and Bifidobacterium probiotics
• Prebiotic fibers (inulin, PHGG, resistant starch)

Lifestyle & Dietary Support

• High-fiber, plant-diverse diet (30+ plant foods weekly)
  Avoiding excessive processed foods and refined sugars
  Adequate hydration and regular bowel motility

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Lactobacillus spp.?
Lactobacillus species are among the most beneficial and well-known bacteria in the human gut. They are lactic acid–producing bacteria found primarily in the small intestine, mouth, and vaginal tract. These bacteria play a vital role in maintaining digestive balance, supporting immune health, and protecting against pathogens. Common species include L. acidophilus, L. rhamnosus, L. plantarum, L. casei, and L. reuteri.

Why is Lactobacillus Important?
Lactobacillus species support gut and systemic health in many ways:

• Produce lactic acid, which helps maintain an acidic pH that discourages pathogenic bacteria
• Support nutrient absorption, particularly minerals like calcium, magnesium, and iron
• Aid in digestion of lactose and carbohydrates
• Strengthen the gut barrier and reduce intestinal permeability
• Modulate immune function and decrease inflammation
• Produce antimicrobial compounds (bacteriocins) that inhibit harmful bacteria and yeast
  

When Lactobacillus levels are low, you may experience:

• Bloating, irregular bowel habits, or mild constipation
• Increased susceptibility to infections or overgrowth (e.g., yeast, Clostridium)
• Weakened mucosal defense and higher inflammation
• Post-antibiotic dysbiosis or reduced resilience to stress
  

How Did My Levels Become Imbalanced?
Imbalances in Lactobacillus levels can occur from:

• Antibiotic or antimicrobial use
• Diets low in fiber and fermented foods
• High sugar or processed food intake
• Chronic stress, poor sleep, or illness
• Reduced stomach acid or digestive enzyme activity
  

What Does My Test Show?
Your GI-MAP results show whether Lactobacillus species are within a healthy range.

• Normal levels suggest a strong mucosal barrier and balanced immune function.
• Low levels may indicate compromised digestion or reduced beneficial flora.
• High levels can occur temporarily with probiotic supplementation and are usually not a concern unless accompanied by symptoms of dysbiosis.
  

Why Might Lactobacillus Affect Symptoms?
Low Lactobacillus can allow harmful microbes to thrive, leading to inflammation, bloating, or irregular stools. Adequate levels help regulate gut motility, support immune tolerance, and protect against pathogens. Restoring Lactobacillus often improves digestion, reduces inflammation, and enhances overall gut resilience.

Important Notes:

• Lactobacillus species are foundational for digestive and immune health.
• Regular intake of probiotics and prebiotic-rich foods helps sustain healthy levels.
• Diversity across multiple Lactobacillus strains is more beneficial than high amounts of one strain.
  

Conventional Management Options

• Balanced diet emphasizing fiber-rich and fermented foods
• Targeted probiotic supplementation after antibiotic use
• Addressing underlying inflammation or low stomach acid
• Managing stress, hydration, and sleep to support microbial balance

Functional Medicine Categories Approach

Microbiome Restoration

• Probiotics containing Lactobacillus acidophilus, L. rhamnosus, L. plantarum, L. casei, L. reuteri
• Prebiotic support (inulin, GOS, PHGG, resistant starch)

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera

Anti-Inflammatory & Immune Support

• Vitamin D
• Omega-3 fatty acids
• Curcumin

Lifestyle & Dietary Support

• Fermented foods (as tolerated): kefir, yogurt, sauerkraut, kimchi, coconut yogurt
• High-fiber, plant-diverse diet (30+ different plant foods weekly)
• Limiting alcohol, refined sugar, and processed foods

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Clostridia (class)?
The Clostridia class refers to a broad group of bacteria within the Firmicutes phylum, which includes both beneficial and potentially harmful species. Many Clostridia are normal residents of a healthy gut microbiome, responsible for producing short-chain fatty acids (SCFAs) — especially butyrate, a vital fuel for colon cells. However, some species (like Clostridium difficile or Clostridium perfringens) can become pathogenic under certain conditions, leading to inflammation or infection.

Why is Clostridia Important?
Balanced Clostridia levels are essential for gut and immune health. Beneficial species help:

• Produce butyrate, which strengthens the intestinal lining and reduces inflammation
• Regulate immune tolerance and reduce autoimmunity risk
• Support proper motility and digestion
• Inhibit growth of harmful pathogens through competitive exclusion
  

However, imbalance or overgrowth can cause problems:

• Low levels may lead to reduced butyrate, impaired mucosal repair, and higher inflammation.
• High levels (especially of harmful strains) may cause bloating, diarrhea, or toxin-mediated gut irritation.
  

How Did My Levels Become Imbalanced?
Disruption in Clostridia balance can result from:

• Antibiotic or antimicrobial use
• Low-fiber, high-sugar diets
• Chronic stress or inflammation
• Prior gastrointestinal infections
• Poor bile flow or digestive enzyme insufficiency
  

What Does My Test Show?
Your GI-MAP results indicate whether Clostridia species are present in normal balance or skewed toward overgrowth or depletion.

• Normal levels suggest healthy fermentation and SCFA production.
• Low levels may indicate reduced microbial diversity or fiber intake.
• High levels could signal dysbiosis, impaired digestion, or inflammation in the colon.
  

Why Might Clostridia Affect Symptoms?
Balanced Clostridia species produce butyrate, which maintains tight junction integrity in the gut and nourishes colon cells. When low, the mucosal barrier weakens, increasing sensitivity, bloating, or irregular bowel habits. Overgrowth of harmful Clostridia species can produce toxins that irritate the colon and disrupt healthy gut function.

Important Notes:

• Clostridia include both beneficial butyrate producers and harmful toxin producers — context matters.
• Supporting beneficial species through fiber and prebiotics encourages a healthier microbial balance.
• Overgrowth should be addressed through targeted antimicrobial and gut repair support.
  

Conventional Management Options

• Antibiotics only when pathogenic Clostridium species (like C. difficile) are identified
• Hydration and electrolyte support if diarrhea is present
• High-fiber diet to encourage butyrate-producing bacteria
• Follow-up stool testing after antimicrobial or probiotic therapy

Functional Medicine Categories Approach

Microbial Balance Support (for overgrowth)

• Berberine
• Oregano oil
• Garlic extract (allicin)
• Black walnut

Butyrate & Gut Lining Support (for low levels)

• Sodium or calcium butyrate supplements
• Resistant starches (green banana flour, cooked & cooled potatoes, rice)
• L-glutamine

Gut Barrier & Mucosal Repair

• Zinc carnosine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Curcumin
• Vitamin D
• Saccharomyces boulardii

Microbiome Restoration

• Probiotics containing Clostridium butyricum, Lactobacillus, and Bifidobacterium species
• Prebiotic fibers (PHGG, inulin, GOS) to promote butyrate producers

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Enterobacter spp.?
Enterobacter species are bacteria that normally exist in small amounts within the human intestines. They belong to the Enterobacteriaceae family — the same family that includes E. coli and Klebsiella. While low levels of Enterobacter can be part of a healthy gut microbiome, elevated levels often signal dysbiosis (imbalance) or bacterial overgrowth, especially in the small intestine. Certain strains can also act as opportunistic pathogens, particularly in individuals with weakened immunity or chronic inflammation.

Why is Enterobacter Important?
In balanced amounts, Enterobacter participates in carbohydrate fermentation and nutrient recycling. However, when overgrown, these bacteria can contribute to:

• Bloating, gas, and abdominal distension
• Loose stools or diarrhea
• Histamine-related symptoms (flushing, headaches, congestion)
• “Leaky gut” and increased inflammation
• Urinary tract or systemic infections (in severe cases or in immunocompromised individuals)
  

High levels may also indicate small intestinal bacterial overgrowth (SIBO) or reduced beneficial flora that normally keep Enterobacter in check.

How Did My Levels Become Imbalanced?
An overgrowth of Enterobacter can result from:

• Frequent or prolonged antibiotic use
• Diets high in sugar, refined carbohydrates, or processed foods
• Low stomach acid (hypochlorhydria) or poor bile flow
• Chronic stress or inflammation
• Gut infections or travel-related illness
• Excessive alcohol intake 

What Does My Test Show?
Your GI-MAP results indicate whether Enterobacter species are within normal range or elevated.

• Normal levels reflect a balanced gut environment with sufficient beneficial flora.
• Elevated levels suggest dysbiosis, bacterial overgrowth, or impaired digestion.
• Low levels may occur after antimicrobial or antibiotic use.
  

Why Might Enterobacter Affect Symptoms?
When Enterobacter overgrows, it can release lipopolysaccharides (LPS) — inflammatory molecules that irritate the gut lining and trigger immune responses. This can lead to bloating, discomfort, or systemic inflammation. Over time, elevated Enterobacter levels may weaken gut barrier integrity and increase sensitivity to certain foods.

Important Notes:

• Overgrowth is often secondary to underlying imbalance — addressing root causes (like low stomach acid or diet) is key.
• Supporting beneficial bacteria can help crowd out Enterobacter naturally.
• Persistent overgrowth should be treated under practitioner guidance, especially in chronic cases.
  

Conventional Management Options

• Antibiotics only if a pathogenic Enterobacter strain is confirmed
• Hydration and dietary adjustments to reduce fermentable carbohydrates
• Probiotic supplementation to restore balance
• Medical evaluation if systemic or recurrent infections are suspected

Functional Medicine Categories Approach

Microbial Balance Support

• Berberine
• Oregano oil
• Garlic extract (allicin)
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera
• Marshmallow root

Anti-Inflammatory & Immune Support

• Vitamin D
• Curcumin
• Saccharomyces boulardii

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus, Bifidobacterium, and spore-based species)
• Prebiotic fibers (PHGG, inulin, resistant starch) introduced gradually

Lifestyle & Dietary Support

• Low-fermentation or modified low-FODMAP diet short-term if bloating severe
• High-fiber, plant-diverse diet long-term for microbial diversity
• Adequate hydration and mindful eating to support motility

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Akkermansia muciniphila?
Akkermansia muciniphila is a beneficial bacterium that resides in the mucus layer of the intestinal lining. It plays a key role in maintaining gut barrier integrity, regulating immune responses, and supporting metabolic health. Unlike many other bacteria that feed on dietary fiber, Akkermansia primarily consumes mucin — the protective mucus secreted by intestinal cells — and in doing so, stimulates the body to produce more of it, strengthening the gut’s protective layer.

Why is Akkermansia Important?
Akkermansia muciniphila is considered a marker of gut health and metabolic balance. Healthy levels help to:

• Maintain and rebuild the intestinal mucus layer (“mucosal firewall”)
• Reduce intestinal permeability (“leaky gut”)
• Support immune regulation and tolerance
• Lower systemic inflammation
• Improve glucose and lipid metabolism
  

However, imbalances in Akkermansia can create problems:

• Low levels are linked to leaky gut, metabolic dysfunction (obesity, insulin resistance), and chronic inflammation.
• High levels may indicate excessive mucus degradation or irritation of the gut lining, sometimes seen in individuals with poor mucosal repair or restrictive diets.
  

How Did My Levels Become Imbalanced?
Akkermansia levels can fluctuate due to:

• Low intake of polyphenols and prebiotic fibers
• Excessive processed food, alcohol, or artificial sweeteners
• Chronic inflammation or gut infections
• Prolonged fasting, restrictive dieting, or overuse of antimicrobial supplements
• Lack of microbial diversity or low mucin production
  

What Does My Test Show?
Your GI-MAP results indicate whether Akkermansia muciniphila is within optimal range.

• Normal levels suggest a strong mucosal barrier and balanced immune system.
• Low levels indicate reduced mucin turnover and potential gut barrier weakness.
• High levels may reflect mucus layer thinning or inflammatory stress on the intestinal lining.
  

Why Might Akkermansia Affect Symptoms?
When Akkermansia is low, the gut lining may become more permeable, allowing toxins and antigens to pass into circulation and trigger immune responses — leading to bloating, food sensitivities, or fatigue. When overgrown, excessive mucin breakdown may worsen irritation, especially in already inflamed or nutrient-depleted gut environments.

Important Notes:

• Akkermansia should neither be too low nor too high — balance is key.
• Optimal levels are associated with better metabolic, immune, and inflammatory balance.
• Polyphenol-rich foods and gut-healing nutrients help regulate Akkermansia naturally.
  
  

Conventional Management Options

• Balanced diet emphasizing whole, plant-based foods
• Avoidance of unnecessary antibiotics and antimicrobial herbs
• Hydration and adequate soluble fiber intake
• Medical evaluation for inflammation if symptoms persist

Functional Medicine Categories Approach

Microbiome Modulation (for low levels)

• Prebiotic fibers (inulin, PHGG, pectin, resistant starch)
• Polyphenol-rich foods (cranberries, pomegranates, blueberries, green tea, cocoa)
• Curcumin or quercetin

Mucosal Barrier Repair (for both low and high levels)

• L-glutamine
• Zinc carnosine
• Aloe vera
• Slippery elm
• Marshmallow root

Anti-Inflammatory & Metabolic Support

• Omega-3 fatty acids
• Vitamin D
• Berberine (for metabolic regulation)

Lifestyle & Dietary Support

• Diverse, high-fiber plant diet (30+ plant foods weekly)
• Avoid ultra-processed foods and excessive fasting
• Adequate sleep, hydration, and stress management to support mucin regeneration

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Faecalibacterium prausnitzii?
Faecalibacterium prausnitzii is one of the most abundant and beneficial bacteria in a healthy human gut. It belongs to the Firmicutes phylum and is a key butyrate-producing species — meaning it generates short-chain fatty acids (SCFAs) that nourish the colon, reduce inflammation, and strengthen the intestinal barrier. Low levels of F. prausnitzii are one of the most consistent findings in individuals with inflammatory bowel conditions, leaky gut, and chronic dysbiosis.

Why is Faecalibacterium prausnitzii Important?
This bacterium is often referred to as a “keystone species” because of its broad role in maintaining gut and immune homeostasis. Healthy levels of F. prausnitzii:

• Produce butyrate, which fuels colon cells and promotes mucosal repair
• Strengthen tight junctions to reduce intestinal permeability (“leaky gut”)
• Reduce inflammation by regulating immune cells and cytokine balance
• Support serotonin production and gut–brain communication
• Promote a balanced microbial environment by lowering pH and inhibiting pathogens
  

When F. prausnitzii levels are low, it may contribute to:

• Gut inflammation and sensitivity
• IBS, IBD, or post-infectious gut symptoms
• Food intolerances and histamine reactivity
• Poor mucosal healing or fatigue due to systemic inflammation
  

How Did My Levels Become Imbalanced?
Low F. prausnitzii often results from:

• Diets low in fiber, resistant starches, or plant diversity
• Frequent antibiotic or antimicrobial use
• Chronic stress or inflammation
• Infections, SIBO, or long-term restrictive dieting
• Lack of prebiotic intake or insufficient short-chain fatty acid (SCFA) production
  

What Does My Test Show?
Your GI-MAP results indicate whether Faecalibacterium prausnitzii is present in a healthy range.

• Normal levels support gut barrier strength and inflammation control.
• Low levels may indicate reduced butyrate production and mucosal weakness.
• High levels are rare but can occur transiently during probiotic or fiber reintroduction.
  

Why Might Faecalibacterium prausnitzii Affect Symptoms?
Low F. prausnitzii means the colon may produce less butyrate — a critical compound for intestinal repair and immune regulation. This can result in increased gut permeability, inflammation, and discomfort. Supporting this species through fiber, prebiotics, and anti-inflammatory nutrients helps restore microbial balance and reduce reactivity.

Important Notes:

• F. prausnitzii cannot be taken as a direct probiotic — it’s anaerobic and highly oxygen-sensitive.
• It can, however, be nourished and supported through diet, prebiotics, and lifestyle.
• Restoring F. prausnitzii levels is a top goal in gut healing and microbiome restoration protocols.
  

Conventional Management Options

• High-fiber, plant-diverse diet (especially resistant starches and soluble fibers)
• Avoidance of unnecessary antibiotics
• Treatment of underlying inflammation or infections
• Adequate hydration and consistent meal patterns

Functional Medicine Categories Approach

Microbiome Restoration

• Prebiotic fibers (inulin, PHGG, GOS, resistant starch)
• Butyrate supplements (sodium or calcium butyrate)
• Probiotics that indirectly support F. prausnitzii (e.g., Lactobacillus plantarum, Bifidobacterium breve)

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera
• Slippery elm

Anti-Inflammatory & Immune Support

• Curcumin
• Vitamin D
• Omega-3 fatty acids
• Polyphenols (green tea, pomegranate, cranberries, berries)

Lifestyle & Dietary Support

• 30+ different plant foods per week (for fiber and polyphenol diversity)
• Adequate sleep and stress reduction (as cortisol can inhibit SCFA-producing bacteria)
• Regular physical activity, which supports SCFA production

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Bacteroidetes?
Bacteroidetes is one of the two major bacterial phyla that dominate the human gut microbiome (the other being Firmicutes). This group includes many beneficial bacteria such as Bacteroides and Prevotella species. Bacteroidetes play a vital role in digesting complex carbohydrates, producing short-chain fatty acids (SCFAs), and supporting metabolic and immune health. A healthy gut typically maintains a balanced ratio between Bacteroidetes and Firmicutes for optimal digestive and systemic function.

Why is Bacteroidetes Important?
Balanced levels of Bacteroidetes help to:

• Break down complex plant fibers and resistant starches into beneficial SCFAs (acetate and propionate)
• Regulate fat storage and glucose metabolism
• Support immune tolerance and reduce inflammation
• Maintain intestinal pH and discourage pathogen overgrowth
  

However, imbalance can create issues:

• Low levels are linked to metabolic dysfunction, obesity, and reduced fiber digestion.
• High levels may occur in low-fat, high-fiber diets or in certain inflammatory states and may be associated with diarrhea or malabsorption.
  

How Did My Levels Become Imbalanced?
Shifts in Bacteroidetes abundance may result from:

• Dietary extremes (very low or very high fiber/fat intake)
• Antibiotic or antimicrobial use
• Chronic inflammation or infections
• Imbalanced Firmicutes:Bacteroidetes ratio (often linked to metabolic stress)
• Low microbial diversity due to limited dietary variety
  

What Does My Test Show?
Your GI-MAP results indicate the relative abundance of Bacteroidetes within your microbiome.

• Normal levels suggest balanced digestion, microbial diversity, and stable metabolic activity.
• Low levels may reflect a lack of dietary fiber, prior antibiotic use, or reduced microbial diversity.
• High levels can indicate a fiber-rich or plant-dominant microbiome, but may also reflect malabsorption or imbalance if accompanied by symptoms.
  

Why Might Bacteroidetes Affect Symptoms?
When Bacteroidetes levels are low, the body produces fewer SCFAs, which weakens gut lining integrity and increases inflammation risk. When overgrown, excessive fermentation may cause gas, bloating, or diarrhea. Maintaining a balanced ratio with Firmicutes helps stabilize metabolism, inflammation, and gut motility.

Important Notes:

• Both too low and too high levels can disrupt balance — context matters.
• The Firmicutes:Bacteroidetes ratio is a key marker for gut metabolic health.
• Diet diversity and fiber intake directly influence Bacteroidetes abundance.
  

Conventional Management Options

• Balanced diet containing soluble and insoluble fiber
• Avoidance of unnecessary antibiotics
• Treatment of underlying inflammation or infections
• Hydration and regular meal patterns for motility support

Functional Medicine Categories Approach

Microbiome Restoration

• Prebiotic fibers (PHGG, inulin, GOS, resistant starch)
• Multi-strain probiotics to support microbial balance
• Polyphenol-rich foods (pomegranates, berries, cocoa, green tea)

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera

Metabolic & Anti-Inflammatory Support

• Curcumin
• Omega-3 fatty acids
• Vitamin D
• Berberine (for high Firmicutes and low Bacteroidetes balance)

Lifestyle & Dietary Support

• Diverse, plant-forward diet (30+ plant foods per week)
• Adequate hydration and mindful eating
• Stress management and regular physical activity to support microbial stability

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Firmicutes?
Firmicutes is one of the two dominant bacterial phyla in the human gut microbiome, alongside Bacteroidetes. This diverse group includes many beneficial species — such as Lactobacillus, Clostridium butyricum, Faecalibacterium prausnitzii, and Roseburia — that play key roles in energy metabolism, gut barrier integrity, and immune regulation. However, when imbalanced, certain Firmicutes species can contribute to inflammation, dysbiosis, or metabolic challenges.

Why is Firmicutes Important?
Balanced Firmicutes levels are essential for digestive and systemic health. Beneficial species help:

• Ferment dietary fibers into short-chain fatty acids (SCFAs), especially butyrate, which supports gut lining repair and reduces inflammation
• Maintain intestinal pH balance and inhibit pathogens
• Regulate metabolism and fat storage
• Support immune tolerance and anti-inflammatory signaling
  

However, imbalance can have opposite effects:

• Low levels may reduce butyrate production, weakening the gut barrier and increasing inflammation.
• High levels — especially when the Firmicutes:Bacteroidetes ratio is elevated — are linked to metabolic dysfunction, weight gain, and inflammation.
  

How Did My Levels Become Imbalanced?
Shifts in Firmicutes abundance can result from:

• High-fat, low-fiber diets
• Chronic stress or inflammation
• Frequent antibiotic or antimicrobial use
• Limited microbial diversity
• Sedentary lifestyle or poor sleep quality
  

What Does My Test Show?
Your GI-MAP results indicate the relative abundance of Firmicutes compared to other microbial groups.

• Normal levels suggest balanced fermentation, metabolism, and mucosal health.
• High levels may point toward metabolic stress or over-fermentation of fats and carbohydrates.
• Low levels may reflect reduced microbial diversity or impaired butyrate production.
  

Why Might Firmicutes Affect Symptoms?
When Firmicutes dominate the microbiome, it may lead to excessive energy extraction from food and fat accumulation, contributing to metabolic imbalance, fatigue, or weight challenges. Low Firmicutes, on the other hand, can lead to inflammation, diarrhea, or reduced gut resilience due to lack of SCFA production.

Important Notes:

• The Firmicutes:Bacteroidetes ratio provides insight into your gut’s metabolic and inflammatory balance.
• The goal is not to eliminate or drastically change Firmicutes, but to restore balance through diet, movement, and gut-supportive nutrients.
• Many Firmicutes are beneficial when properly regulated.
  

Conventional Management Options

• Balanced, fiber-rich diet with moderate healthy fats
• Addressing inflammation and metabolic health
• Avoiding unnecessary antibiotic use
• Supporting digestion through regular meals and hydration

Functional Medicine Categories Approach

Microbiome Restoration

• Prebiotic fibers (PHGG, GOS, resistant starch) to support SCFA producers
• Probiotic species from the Firmicutes family (e.g., Lactobacillus plantarum, Clostridium butyricum)

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera

Anti-Inflammatory & Metabolic Support

• Curcumin
• Omega-3 fatty acids
• Vitamin D
• Berberine (for elevated Firmicutes:Bacteroidetes ratio)

Lifestyle & Dietary Support

• High-fiber, plant-diverse diet (30+ plant foods per week)
• Regular movement and exercise (improves microbial ratio)
• Adequate sleep and stress management for immune-microbiome regulation

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is the Firmicutes:Bacteroidetes Ratio?
The Firmicutes:Bacteroidetes (F:B) ratio measures the balance between the two dominant bacterial phyla in your gut microbiome — Firmicutes and Bacteroidetes. Together, these groups make up more than 90% of the gut’s bacterial population. The ratio provides insight into overall microbial balance, metabolic function, and gut health. While there is no single “perfect” number, a balanced ratio supports healthy digestion, metabolism, and immune activity.

Why is the F:B Ratio Important?
The F:B ratio influences how your body processes nutrients, stores energy, and manages inflammation.

• A balanced ratio helps maintain a diverse microbiome, efficient fiber fermentation, and healthy weight regulation.
• A high ratio (more Firmicutes relative to Bacteroidetes) has been associated with:
• Increased calorie extraction from food
• Weight gain or metabolic syndrome
• Low-grade inflammation and insulin resistance
  
• A low ratio (more Bacteroidetes relative to Firmicutes) may occur with:
• Restrictive diets or chronic inflammation
• Malabsorption or diarrhea
• Reduced production of butyrate and other short-chain fatty acids (SCFAs)
  

How Did My Ratio Become Imbalanced?
Several factors influence the F:B ratio, including:

• Dietary patterns (low fiber, high fat, high sugar)
• Chronic stress and poor sleep
• Frequent antibiotic or antimicrobial use
• Lack of microbial diversity
• Sedentary lifestyle or inflammation 

What Does My Test Show?
Your GI-MAP results display the relative proportions of Firmicutes and Bacteroidetes, providing a snapshot of your gut’s metabolic state.

• Optimal or balanced ratio: Suggests a resilient, stable microbiome.
• Elevated ratio: Indicates a possible tendency toward inflammation, weight gain, or dysbiosis.
• Low ratio: May reflect undernutrition, reduced diversity, or chronic inflammatory conditions.
  

Why Might an Imbalanced Ratio Affect Symptoms?
When the F:B ratio is high, the gut may extract more calories from food and trigger low-grade inflammation, leading to fatigue, bloating, and metabolic sluggishness. When too low, the microbiome may lack diversity and fail to produce sufficient SCFAs, resulting in diarrhea, nutrient malabsorption, or poor gut lining repair.

Important Notes:

• The F:B ratio is a trend marker, not a diagnosis — it should be interpreted alongside other findings.
• Aim to rebalance rather than drastically alter the ratio.
• Diet, movement, and fiber diversity are the most effective long-term tools for normalization.
  

Conventional Management Options

• Balanced, plant-rich diet emphasizing soluble and insoluble fibers
• Weight management and anti-inflammatory nutrition strategies
• Regular physical activity and hydration
• Minimizing unnecessary antibiotics and processed food intake

Functional Medicine Categories Approach

Microbiome Restoration

• Prebiotic fibers (inulin, PHGG, GOS, resistant starch) to support Bacteroidetes growth
• Probiotics containing Bifidobacterium, Lactobacillus, and Clostridium butyricum species
• Polyphenol-rich foods (pomegranates, blueberries, cocoa, green tea)

Metabolic & Inflammatory Regulation

• Berberine (helps lower high F:B ratio)
• Omega-3 fatty acids
• Curcumin
• Vitamin D

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera

Lifestyle & Dietary Support

• Diverse, high-fiber diet (goal: 30+ plant foods per week)
• Consistent movement (walking, strength training, or yoga)
• Adequate sleep and stress reduction to regulate cortisol and gut signaling

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Bacillus spp.?
Bacillus species are a group of spore-forming bacteria found in soil, water, and sometimes in the human gastrointestinal tract. Some strains are beneficial and used in probiotics (e.g., Bacillus subtilis, Bacillus coagulans), while others can act as opportunistic pathogens if overgrown or present in unhealthy forms. Their natural ability to form hardy spores allows them to survive harsh environments — including stomach acid — and influence gut microbial balance.

Why is Bacillus Important?
Certain Bacillus strains are helpful for gut health, as they:

• Support microbial diversity by competing with pathogens
• Aid in digestion and production of enzymes that break down proteins and carbohydrates
• Modulate immune system activity
• Reduce inflammation and oxidative stress
• Promote gut barrier integrity through SCFA production
  

However, excessive or pathogenic strains may cause:

• Bloating, gas, or diarrhea
• Gut irritation or inflammation
• Opportunistic infections (rare, but possible in immunocompromised individuals)
  

How Did My Levels Become Imbalanced?
Imbalance in Bacillus species can occur due to:

• Overuse of antibiotics or antimicrobials (disrupting microbial balance)
• Environmental exposure (soil, contaminated food, or water)
• Reduced beneficial flora that would normally keep Bacillus in check
• Poor diet or chronic inflammation weakening gut resilience
  

What Does My Test Show?
Your GI-MAP results indicate whether Bacillus species are present in normal amounts or elevated.

• Normal levels suggest a balanced, supportive microbial ecosystem.
• Low levels are not typically concerning since these species are transient.
• High levels may indicate opportunistic overgrowth or gut barrier disruption.
  

Why Might Bacillus Affect Symptoms?
Beneficial strains can enhance digestion and microbial diversity, while opportunistic forms may produce toxins or trigger inflammation. Overgrowth may cause gastrointestinal discomfort, especially if combined with other dysbiotic bacteria or after antimicrobial therapy.

Important Notes:

• Context matters — not all Bacillus are harmful.
  
  
• Some probiotic supplements intentionally include beneficial Bacillus strains (e.g., Bacillus coagulans, Bacillus clausii).
  
  
• Elevated levels on stool testing may warrant evaluation for underlying dysbiosis or environmental exposure.
  

Conventional Management Options

Hydration and supportive care if mild digestive symptoms occur

• Avoidance of unnecessary antimicrobial overuse
• Antibiotics only if infection is confirmed and clinically significant
• Follow-up testing to monitor balance after intervention

Functional Medicine Categories Approach

Microbial Balance Support (for overgrowth)

• Berberine
• Oregano oil
• Garlic extract (allicin)
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera
• Marshmallow root

Anti-Inflammatory & Immune Support

• Vitamin D
• Curcumin
• Saccharomyces boulardii

Microbiome Restoration (for depletion)

• Probiotic blends containing Bacillus subtilis, Bacillus clausii, Bacillus coagulans (clinically studied beneficial strains)
• Prebiotic fibers (PHGG, inulin, GOS) to feed protective flora

Lifestyle & Dietary Support

• Diverse plant-based diet to maintain microbial balance
• Avoid overly sterile environments or unnecessary antimicrobial exposure
• Stress management and regular exercise to improve immune-microbiome communication

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Enterococcus faecalis?
Enterococcus faecalis is a species of bacteria that normally lives in small amounts in the human intestines as part of the commensal gut flora. It plays a minor role in digestion and nutrient metabolism but can become opportunistic when overgrown or when the gut barrier is weakened. This organism is notable because certain strains are linked to infections outside the gut (like urinary tract or bloodstream infections) and are known for developing resistance to antibiotics.

Why is Enterococcus faecalis Important?
In a healthy microbiome, E. faecalis remains balanced and non-problematic. However, when overgrown, it can contribute to inflammation, dysbiosis, or infection.
Balanced levels may:

• Participate in carbohydrate fermentation and lactic acid production
• Help maintain microbial diversity
  

Elevated levels may lead to:

• Bloating, gas, and abdominal discomfort
• Signs of SIBO (small intestinal bacterial overgrowth)
• Increased intestinal permeability (“leaky gut”)
• Possible urinary or systemic infections (if bacteria translocate beyond the gut)
  

How Did My Levels Become Imbalanced?
E. faecalis can become elevated or problematic due to:

• Antibiotic use (which disrupts healthy bacterial competition)
• Low stomach acid or poor digestive enzyme output
• Diets high in sugar, refined carbohydrates, or processed foods
• Chronic inflammation or immune suppression
• Hospital exposure or prior medical procedures (as it is a common healthcare-associated organism)
  

What Does My Test Show?
Your GI-MAP results indicate whether E. faecalis is within normal range, elevated, or depleted.

• Normal levels indicate healthy microbial diversity and mucosal stability.
• High levels suggest opportunistic overgrowth or dysbiosis.
• Low levels are rarely significant unless linked to global microbiome depletion (e.g., after antibiotic use).
  

Why Might Enterococcus faecalis Affect Symptoms?
When overgrown, E. faecalis can produce substances that irritate the gut lining, promote inflammation, and interfere with beneficial bacteria. In more severe cases, translocation (movement outside the gut) may trigger immune activation or infection. Elevated levels are often secondary to an imbalanced microbial ecosystem or barrier dysfunction.

Important Notes:

• E. faecalis is part of normal gut flora but becomes problematic in excess.
   
• It is resistant to many antibiotics, so functional and lifestyle strategies are essential for rebalancing.
• Reducing inflammation and strengthening the gut barrier helps restore balance.
  

Conventional Management Options

• Antibiotics (only if infection confirmed outside the gut)
• Supportive hydration and nutrition
• Treatment of underlying dysbiosis or inflammation
• Follow-up testing to monitor progress

Functional Medicine Categories Approach

Microbial Balance Support

• Berberine
• Oregano oil
• Garlic extract (allicin)
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera
• Marshmallow root

Anti-Inflammatory & Immune Support

• Curcumin
• Vitamin D
• Saccharomyces boulardii

Microbiome Restoration

• Multi-strain probiotics (especially Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (PHGG, GOS, inulin) to restore balance gradually

Lifestyle & Dietary Support

• Diverse, high-fiber diet rich in plant polyphenols (berries, cocoa, green tea)
• Avoid refined sugars, alcohol, and processed foods
• Support healthy digestion with mindful eating and adequate hydration

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Enterococcus faecium?
Enterococcus faecium is a species of bacteria commonly found in the human gastrointestinal tract, as well as in soil, plants, and fermented foods. While small amounts can be a normal part of gut flora, certain strains of E. faecium have developed antibiotic resistance (including vancomycin-resistant enterococci, or VRE), making them notable in both hospital and gut-related contexts. In healthy individuals, E. faecium helps maintain microbial diversity, but overgrowth or imbalance may contribute to gut inflammation or infection risk.

Why is Enterococcus faecium Important?
In balanced amounts, E. faecium can:

• Contribute to lactic acid production, helping to regulate intestinal pH
• Compete with harmful bacteria, supporting microbial balance
• Participate in the fermentation of carbohydrates
  

However, in excess, it can:

• Promote inflammation and gut barrier dysfunction
• Contribute to symptoms of dysbiosis or SIBO (small intestinal bacterial overgrowth)
• Trigger urinary tract or bloodstream infections in immunocompromised individuals
• Transfer antibiotic resistance genes to other bacteria within the microbiome
  

How Did My Levels Become Imbalanced?
An overgrowth of E. faecium may result from:

• Repeated or prolonged antibiotic use
• Low stomach acid or impaired bile flow
• Diets high in processed foods or sugar
• Hospital or healthcare exposure (common source of resistant strains)
• Chronic inflammation, immune suppression, or gut barrier weakness
  

What Does My Test Show?
Your GI-MAP results indicate whether E. faecium levels are balanced, low, or elevated.

• Normal levels reflect a stable, resilient microbiome.
• High levels may suggest dysbiosis, post-antibiotic imbalance, or opportunistic overgrowth.
• Low levels are typically not concerning unless the overall microbiome diversity is low.
  

Why Might Enterococcus faecium Affect Symptoms?
Overgrowth can cause irritation to the intestinal lining, bloating, and discomfort. It may also increase intestinal permeability (“leaky gut”), allowing endotoxins and inflammatory compounds to enter circulation. In individuals with compromised immunity, elevated E. faecium can increase susceptibility to systemic infections.

Important Notes:

• E. faecium can act as both a commensal and opportunistic organism — context and levels matter.
• Resistant strains are primarily a concern in hospital settings, not healthy community populations.
• Supporting gut barrier repair and microbial balance helps minimize its overgrowth risk.
  

Conventional Management Options

• Antibiotics (only if a resistant or systemic infection is confirmed)
• Supportive hydration and gut rest during acute symptoms
• Dietary modification to restore microbial diversity
• Follow-up testing to monitor microbial rebalancing

Functional Medicine Categories Approach

Microbial Balance Support

• Berberine
• Oregano oil
• Garlic extract (allicin)
• Black walnut

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera
• Marshmallow root

Anti-Inflammatory & Immune Support

• Curcumin
• Vitamin D
• Saccharomyces boulardii

Microbiome Restoration

• Multi-strain probiotics (with Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (PHGG, inulin, GOS)

Lifestyle & Dietary Support

• Plant-diverse, high-fiber diet to promote beneficial flora
• Avoid excessive sugar, alcohol, and processed food
• Support healthy digestion with regular meals and hydration
• Minimize unnecessary antibiotic or antimicrobial exposure

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Morganella spp.?
Morganella species — most commonly Morganella morganii — are opportunistic bacteria that belong to the Enterobacteriaceae family. They are normally present in very small amounts in the intestines but are not considered beneficial. When overgrown or translocated outside the gut, Morganella can act as a pathogen, contributing to intestinal inflammation, urinary tract infections, and, in severe cases, systemic infections. Elevated Morganella levels on a GI-MAP often indicate dysbiosis or small intestinal bacterial overgrowth (SIBO).

Why is Morganella Important?
In small amounts, Morganella may coexist quietly within the gut community. However, when levels rise, it can produce urease, an enzyme that breaks down urea into ammonia — leading to:

• Bloating, belching, or gas (from excess ammonia production)
• Altered gut pH, which disrupts beneficial bacteria
• Gut barrier irritation and inflammation
• Increased histamine levels, contributing to food sensitivities or skin reactions
• Systemic symptoms like fatigue or brain fog in sensitive individuals
  

How Did My Levels Become Imbalanced?
Morganella overgrowth may occur due to:

• Frequent or prolonged antibiotic use
• Low stomach acid (allowing upper GI colonization)
• Diets high in processed foods or low in fiber
• Chronic constipation or slow motility
• Immune suppression or high stress levels
• Post-infectious dysbiosis following foodborne illness
  

What Does My Test Show?
Your GI-MAP results indicate whether Morganella DNA was detected and at what relative level.

• Normal or undetectable levels are ideal, suggesting a stable gut ecosystem.
• Elevated levels indicate dysbiosis, overgrowth, or inflammation-driven imbalance.
  

Why Might Morganella Affect Symptoms?
When Morganella overgrows, it can release inflammatory compounds and contribute to the buildup of ammonia and histamine in the gut. This may lead to bloating, discomfort, or hypersensitivity to high-histamine foods. Over time, elevated Morganella can strain liver detoxification and contribute to fatigue or skin issues due to systemic inflammation.

Important Notes:

• Morganella overgrowth is often secondary to other gut imbalances, such as low beneficial flora or poor motility.
• Addressing digestive function, microbial balance, and gut barrier repair helps restore equilibrium.
• High-histamine diets may temporarily worsen symptoms while Morganella levels are elevated.
  

Conventional Management Options

• Targeted antibiotics (only when clinically indicated)
• Hydration and electrolyte support during acute GI symptoms
• Addressing constipation and supporting bowel regularity
• Low-histamine, anti-inflammatory diet during rebalancing phase

Functional Medicine Categories Approach

Microbial Balance Support

• Berberine
• Oregano oil
• Garlic extract (allicin)
• Black walnut

Urease and Histamine Regulation

• N-acetylcysteine (NAC)
• Quercetin
• Vitamin C

Gut Barrier & Mucosal Support

• L-glutamine
• Zinc carnosine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Curcumin
• Vitamin D
• Saccharomyces boulardii

Microbiome Restoration

• Probiotics containing Lactobacillus and Bifidobacterium species
• Prebiotic fibers (PHGG, inulin, GOS — introduced gradually)

Lifestyle & Dietary Support

• Temporarily reduce high-histamine foods (aged cheese, fermented foods, alcohol)
  Eat a diverse, plant-rich diet long term for microbiome recovery
  Support digestion with mindful eating, adequate hydration, and stress reduction

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Pseudomonas spp.?
Pseudomonas species are a group of bacteria commonly found in soil, water, and moist environments. In small amounts, they can occasionally appear in the human gut without causing harm, but they are generally considered opportunistic pathogens rather than beneficial flora. The most clinically relevant species, Pseudomonas aeruginosa, is known for its resistance to antibiotics and ability to form biofilms — protective layers that make it harder for the immune system and treatments to eliminate.

Why is Pseudomonas Important?
At healthy levels, Pseudomonas usually remains harmless. However, when overgrown or translocated beyond the gut, it can contribute to:

• Bloating, gas, or abdominal discomfort
• Intestinal inflammation and leaky gut
• Diarrhea or mucus in stool
• Respiratory or urinary infections (in severe or systemic cases)
• Fatigue, food sensitivities, or histamine intolerance from ongoing inflammation
  

How Did My Levels Become Imbalanced?
Pseudomonas imbalance can occur from:

• Frequent or prolonged antibiotic use (which suppresses beneficial bacteria and allows resistant strains to flourish)
• Chronic inflammation or immune suppression
• Low stomach acid or impaired digestion
• Environmental exposure (contaminated water, medical settings, or wounds)
• Heavy metal or toxin burden that supports biofilm formation
  

What Does My Test Show?
Your GI-MAP results indicate whether Pseudomonas DNA was detected in your stool.

• Absent or low levels are considered normal.
• Elevated levels suggest dysbiosis, biofilm-related overgrowth, or microbial imbalance.
  

Why Might Pseudomonas Affect Symptoms?
Pseudomonas produces endotoxins (lipopolysaccharides, or LPS) that can irritate the intestinal lining and trigger inflammation. When overgrown, it may also contribute to biofilm buildup, making other pathogens harder to eliminate. This can lead to digestive symptoms, immune dysregulation, or systemic fatigue.

Important Notes:

• Pseudomonas thrives in low-oxygen, inflamed environments — improving gut oxygenation and barrier function helps suppress it naturally.
• Biofilm disruptors and antioxidants can support clearance when guided by a practitioner.
• Reinfection risk increases with chronic exposure to contaminated water or healthcare settings.
  

Conventional Management Options

• Targeted antibiotics (for clinically confirmed Pseudomonas aeruginosa infection)
• Hydration and electrolyte replacement during acute symptoms
• Treatment of underlying inflammation and immune imbalance
• Environmental hygiene and water safety review if recurrent

Functional Medicine Categories Approach

Microbial Balance & Biofilm Disruption

• Berberine
• Oregano oil
• Garlic extract (allicin)
• N-acetylcysteine (NAC)
• EDTA (practitioner-guided)

Gut Barrier & Mucosal Repair

• L-glutamine
• Zinc carnosine
• Aloe vera
• Marshmallow root

Anti-Inflammatory & Immune Support

• Curcumin
• Vitamin D
• Vitamin C
• Saccharomyces boulardii

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (PHGG, inulin, GOS — added gradually)

Lifestyle & Environmental Support

• Avoid exposure to stagnant or unfiltered water sources
• Support detoxification pathways (adequate hydration, sweating, antioxidant intake)
• Reduce processed foods and refined sugars that fuel biofilm formation
• Manage stress and optimize sleep to enhance immune resilience

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Pseudomonas aeruginosa?
Pseudomonas aeruginosa is a pathogenic species within the Pseudomonas genus. It is an opportunistic bacterium that rarely causes illness in healthy individuals but can become problematic in cases of gut dysbiosis, low immunity, or chronic inflammation. This organism is particularly resilient because it forms biofilms (protective layers that make it difficult to eliminate) and is often resistant to multiple antibiotics. When detected on a GI-MAP, it typically reflects microbial imbalance or systemic burden rather than a localized gut infection alone.

Why is Pseudomonas aeruginosa Important?
While it’s not a typical member of the healthy gut flora, small transient amounts can sometimes appear after environmental exposure. Elevated or persistent levels may lead to:

• Digestive symptoms such as bloating, loose stools, or mucus in stool
• Gut inflammation and increased intestinal permeability (“leaky gut”)
• Secondary overgrowth of other opportunistic microbes
• Increased oxidative stress and fatigue
• Risk of urinary or respiratory infections in vulnerable individuals
  

How Did My Levels Become Imbalanced?
Overgrowth or presence of P. aeruginosa may occur due to:

• Repeated antibiotic use (disrupting protective flora and allowing resistant strains to colonize)
• Exposure to contaminated water, soil, or hospital environments
• Low stomach acid or compromised gut barrier
• Chronic illness, inflammation, or immune suppression
• Heavy metal exposure or environmental toxins supporting biofilm persistence
  

What Does My Test Show?
Your GI-MAP results detected Pseudomonas aeruginosa DNA in your stool sample.

• Absent or trace levels are not concerning and may reflect transient exposure.
• Elevated levels suggest dysbiosis, bacterial overgrowth, or biofilm-associated imbalance requiring support.
  

Why Might Pseudomonas aeruginosa Affect Symptoms?
This organism produces endotoxins (LPS) and other inflammatory compounds that can irritate the gut lining and immune system. When overgrown, it disrupts beneficial flora, contributes to gas, bloating, or fatigue, and may perpetuate chronic inflammation. Its biofilm-forming ability allows it to “hide” from both immune defenses and treatment efforts.

Important Notes:

• P. aeruginosa thrives in inflamed, oxygen-poor environments — improving gut oxygenation and microbial diversity helps suppress it.
• Biofilm disruption and mucosal repair are key components of recovery.
• Reinfection can occur with repeated environmental exposure (e.g., water, humidifiers, medical equipment).
  

Conventional Management Options

• Targeted antibiotics (only when clinically indicated and guided by culture sensitivity)
• Hydration, rest, and nutritional support during recovery
• Medical evaluation if systemic or respiratory symptoms develop
• Follow-up stool testing to confirm clearance after treatment

Functional Medicine Categories Approach

Microbial Balance & Biofilm Disruption

• Berberine
• Oregano oil
• Garlic extract (allicin)
• N-acetylcysteine (NAC)
• EDTA (practitioner-guided)

Gut Barrier & Mucosal Repair

• L-glutamine
• Zinc carnosine
• Aloe vera
• Slippery elm
• Marshmallow root

Anti-Inflammatory & Immune Support

• Curcumin
• Vitamin D
• Vitamin C
• Saccharomyces boulardii

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus, Bifidobacterium, and spore-based species)
• Prebiotic fibers (PHGG, inulin, resistant starch — introduced slowly)

Lifestyle & Environmental Support

• Avoid exposure to stagnant or unfiltered water sources
• Support detoxification via sweating, hydration, and antioxidant-rich foods
• Limit refined sugars and processed foods that promote biofilm resilience
• Prioritize sleep and stress reduction to improve immune response

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.

What is Staphylococcus spp.?
Staphylococcus species are bacteria commonly found on the skin, mucous membranes, and sometimes in the gastrointestinal tract. In small amounts, they can be part of the body’s normal microbial community. However, certain species — especially Staphylococcus aureus — can become opportunistic pathogens if they overgrow or translocate to other parts of the body. On a GI-MAP, elevated Staphylococcus spp. levels may reflect gut dysbiosis, impaired immune function, or bacterial translocation.

Why is Staphylococcus Important?
At balanced levels, Staphylococcus species generally coexist harmlessly. But when overrepresented, they can contribute to:

• Gas, bloating, or abdominal discomfort
• Gut inflammation and increased permeability (“leaky gut”)
• Skin conditions such as eczema, acne, or rashes (through gut-skin axis disruption)
• Recurrent sinus or respiratory issues
• Biofilm formation, making infections more persistent or resistant to treatment
  

Certain strains, such as Staphylococcus aureus, can produce toxins that worsen inflammation and suppress immune function.

How Did My Levels Become Imbalanced?
An increase in Staphylococcus species can occur due to:

• Frequent antibiotic or antimicrobial use
• Low beneficial bacteria (Lactobacillus and Bifidobacterium)
• High sugar or processed food intake
• Low stomach acid or impaired digestion
• Skin or nasal colonization leading to reintroduction via the oral route
• Chronic stress or inflammation
  

What Does My Test Show?
Your GI-MAP results indicate whether Staphylococcus DNA is present at normal or elevated levels.

• Normal levels are typically harmless and part of a balanced microbiome.
• Elevated levels suggest dysbiosis, translocation from skin/nasal sources, or gut inflammation.
• Low or absent levels are normal and not concerning.
  

Why Might Staphylococcus Affect Symptoms?
When overgrown, Staphylococcus species can produce enterotoxins and inflammatory compounds that irritate the intestinal lining and immune system. This may manifest as bloating, food reactivity, fatigue, or skin flare-ups. Because of their ability to form biofilms, they can be difficult to clear without disrupting the protective layers they build.

Important Notes:

• The presence of Staphylococcus doesn’t always mean infection — context and symptoms matter.
• Supporting gut integrity and microbial diversity helps reduce colonization.
• Recurrent skin or nasal issues can serve as reservoirs for reintroduction.
  

Conventional Management Options

• Antibiotics only if clinical infection is confirmed
• Topical or nasal treatments (for S. aureus colonization) when prescribed
• Hydration and anti-inflammatory nutrition
• Addressing external reservoirs (skin, nasal passages) if recurrent

Functional Medicine Categories Approach

Microbial Balance & Biofilm Disruption

• Berberine
• Oregano oil
• Garlic extract (allicin)
• N-acetylcysteine (NAC)

Gut Barrier & Mucosal Repair

• L-glutamine
• Zinc carnosine
• Aloe vera
• Marshmallow root
• Slippery elm

Anti-Inflammatory & Immune Support

• Vitamin D
• Curcumin
• Vitamin C
• Saccharomyces boulardii

Microbiome Restoration

• Multi-strain probiotics (Lactobacillus and Bifidobacterium species)
• Prebiotic fibers (PHGG, GOS, resistant starch)

Lifestyle & Environmental Support

• Reduce refined sugar and processed foods (fuel for Staphylococcus growth)
• Address possible skin or nasal colonization if recurrent
• Support detoxification through hydration, sweating, and antioxidant intake
• Practice proper hygiene and avoid sharing personal items to limit re-exposure

Disclaimer:
Gut Health Education (GHE) recommends following the manufacturer’s suggested dosage on each supplement label unless otherwise directed by a licensed healthcare professional. The options provided within each category are intended as alternatives — not to be taken all together. Always consult with your healthcare provider before beginning, changing, or combining any supplement regimen.